Evidence map›Paper›PMID 40244057›Full record

ArticleInternational journal of molecular sciences2025

Increased Expression of Superoxide Dismutase 2 Is an Indicator of Worse Prognosis of Oropharyngeal Cancer.

Yoshitaka Aoki, Satoru Kondo, Eiji Kobayashi, Makiko Moriyama-Kita, Hirotomo Dochi, Shigetaka Komura, Yosuke Nakanishi, Kazuhira Endo, Naohiro Wakisaka, Tomokazu Yoshizaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yoshitaka AokiDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Satoru KondoDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Eiji KobayashiDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.ORCID 0000-0001-7318-8057
Makiko Moriyama-KitaDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.ORCID 0000-0002-0778-3939
Hirotomo DochiDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.ORCID 0000-0001-5711-7240
Shigetaka KomuraDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Yosuke NakanishiDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Kazuhira EndoDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.ORCID 0000-0002-5401-8594
Naohiro WakisakaDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.
Tomokazu YoshizakiDivision of Otolaryngology and Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Ishikawa, Japan.

Funding

the Ministry of Education, Science, Sports, Culture and Technology of Japan 16H05480the Ministry of Education, Science, Sports, Culture and Technology of Japan 17H01590
6 · The paper itself

Abstract

Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPC), with distinct HPV-positive and HPV-negative subtypes. Reactive oxygen species have been implicated in the carcinogenesis of several malignancies. Superoxide dismutase 2 (SOD2), a mitochondrial enzyme, is highly influenced by oxidative stress. This study investigated whether SOD1 and SOD2 expression in OPC affects primary tumor progression, lymph node metastasis, stage, and overall survival (OS). Biopsy or surgically resected specimens from 72 patients with OPC were analyzed via immunohistochemical staining for SOD1 and SOD2. The proportion of stained cells within the tumor area was assessed. Associations between SOD1 and SOD2 expression, T classification, N classification, and stage were evaluated. Factors correlated with OS in OPC were also examined. No significant differences in SOD1 or SOD2 expression were observed concerning T or N classification, or stage. However, high SOD2 expression was identified as a significant poor prognostic factor for OS. Regardless of HPV status, SOD2 expression predicts poor prognosis in OPC. Evaluating SOD2 expression may help predict OPC prognosis.

Indexed as

Biomarkers, TumorOropharyngeal NeoplasmsSuperoxide DismutaseAdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPapillomavirus InfectionsPrognosisSuperoxide Dismutase-1Superoxide Dismutase 2Biomarkers, TumorSOD1 protein, humanSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2HPVoropharyngeal cancerSOD2

Identifiers

PMID40244057
PMCPMC11989547

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.