Evidence map›Paper›PMID 40244137›Full record

ArticleInternational journal of molecular sciences2025

Protective Effects of Fucoidan on Iodoacetamide-Induced Functional Dyspepsia via Modulation of 5-HT Metabolism and Microbiota.

Tianxu Liu, Muyuan Ma, Yonglin Wu, Ismail Muhammad Asif, Daosen Chen, Lichong Liu, Minghui Zhang, Yijie Chen, Bin Li, Ling Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianxu LiuCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Muyuan MaCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Yonglin WuCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Ismail Muhammad AsifCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Daosen ChenCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Lichong LiuCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Minghui ZhangCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Yijie ChenCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Bin LiCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0001-7763-4245
Ling WangCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-1076-0500

Funding

National Key Research and Development Program-Research and Application of Green Manufacturing Key Technology of Food Quality Improvement 2022YFD210130
6 · The paper itself

Abstract

As the major polysaccharide in brown algae, fucoidan possesses broad biological abilities and has been reported to improve gastrointestinal health. Functional dyspepsia, a common non-organic disease, is a complex of symptoms mainly characterized by pathogenesis, such as visceral hypersensitivity, gastric dysmotility, and inflammation. To date, the effects of fucoidan in regulating functional dyspepsia with visceral sensitivity remains unclear. In the current study, iodoacetamide was employed to establish a mouse model of visceral hypersensitivity. Meanwhile, fucoidan was orally administrated for fourteen days. Indicators were conducted to evaluate the potential of fucoidan as the ingredient of complementary and alternative medicine for functional dyspepsia, such as levels of serum hormones, expression of receptors, and gut microbial profile. The results show that oral administration of fucoidan led to significant reductions in the secretion of 5-hydroxytryptamine, cortisol, and corticosterone. Additionally, it decreased the expression of 5-hydroxytryptamine

Indexed as

DyspepsiaGastrointestinal MicrobiomeIodoacetamidePolysaccharidesSerotoninAnimalsDisease Models, AnimalMaleMicefucoidanIodoacetamidePolysaccharidesSerotonin5-HTfucoidanfunctional dyspepsiamicrobiotavisceral hypersensitivity

Identifiers

PMID40244137
PMCPMC11989908

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.