Evidence map›Paper›PMID 40244197›Full record

ArticleInternational journal of molecular sciences2025

Ablation of Mouse Selenium-Binding Protein 1 and 2 Elevates LDL by Disruption of Cholesterol Efflux and Lipid Metabolism.

Shuangli Zhao, Yingxia Song, Yuko Nakashima, Xing Zou, Takayuki Koga, Takumi Ishida, Renshi Li, Yuko Hirota, Yoshitaka Tanaka, Yuji Ishii

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuangli ZhaoDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yingxia SongDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yuko NakashimaDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Xing ZouDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Takayuki KogaLaboratory of Hygienic Chemistry, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan.
Takumi IshidaSchool of Pharmacy, International University of Health and Welfare Fukuoka, Ohkawa 831-8501, Japan.ORCID 0000-0001-5535-6029
Renshi LiSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.ORCID 0000-0002-8109-586X
Yuko HirotaDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yoshitaka TanakaDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yuji IshiiDivision of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-2069-0219

Funding

Japan Society for the Promotion of Science JSPS Fellows JSPS KAKENHI 24KJ1773, Recipient SZJapan Society for the Promotion of Science Scientific Research (A) JSPS KAKENHI JP17H00788, Recipient YIJapan Society for the Promotion of Science Scientific Research (A) JSPS KAKENHI JP21H04928, Recipient YIthe Ministry of Health, Labor and Welfare, Japan Research on Food Safety (H30-Designated Research-005, Recipient YI)the Ministry of Health, Labor and Welfare, Japan Research on Food Safety ( R6-Designated Research JP24KA2001, Recipient YI)the Ministry of Health, Labor and Welfare, Japan the Ministry of Health, Labor and Welfare, Japan [Research on Food Safety (R3-Designated Research JP21KA2003, Recipient YI)
6 · The paper itself

Abstract

Selenium-binding protein 1 (SeBP1) is an anticancer factor that affects lipid metabolism in mouse kidneys via the peroxisome proliferator-activated receptor-alpha (PPARA) pathway. However, its physiological role in the liver is difficult to explain because of the presence of the highly homologous selenium-binding protein 2 (SeBP2). To investigate the role of these proteins in the liver, we generated

Indexed as

CholesterolLipid MetabolismSelenium-Binding ProteinsAllelesAnimalsCholesterol, LDLFemaleHep G2 CellsHumansLiverMaleMiceMice, KnockoutOxidation-ReductionSuperoxide DismutaseCholesterolCholesterol, LDLSelenbp1 protein, mouseSelenbp2 protein, mouseSelenium-Binding ProteinsSuperoxide Dismutasecholesterol/effluxlipids/oxidationliverPPARstriglycerides

Identifiers

PMID40244197
PMCPMC11989624

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.