ArticleDiscover oncology2025
Association between type 2 diabetes and gastric cancer in Europeans and East Asians based on two sample Mendelian randomization.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Type 2 diabetes mellitus and cancer: A systematic review and meta-analysis of Mendelian randomization studies.Frontiers in endocrinology · 2026Pooled it
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Authors and funding
7 authors.
Funding
Abstract
backgroundThere are conflicting results and potential methodological flaws of previous observational studies on the association between T2DM and the risk of gastric cancer.This two-sample Mendelian randomization (MR) study aimed to investigate the causal association between type 2 diabetes mellitus (T2DM) and gastric cancer in different ethnic populations.
methodsExposure variables were obtained from genome-wide association studies (GWAS) of T2DM in European population (finn-b-E4_DM2; 32,469) and East Asian population (ebi-a-GCST90018706; n = 45,383). Concomitantly, we utilized summary-level genetic data for gastric cancer in Europeans population (ebi-a-GCST90018849; n = 1029) and East Asians population (ebi-a-GCST90018629; n = 7,921) as the outcome measure. Causal associations between T2DM and gastric cancer in the same ethnic groups were primarily determined using the inverse-variance weighted (IVW) method.
resultsA total of 62 and 106 single nucleotide polymorphisms associated with T2DM were selected for in Europeans and East Asians, respectively. The IVW analysis indicated that there was a significant inverse association between T2DM and gastric cancer in Europeans (odds ratio [OR] 0.917; 95% confidence interval [CI] 0.855-0.984) and East Asians (OR 0.881; 95% CI 0.845-0.918). The weighted median and Weighted mode regression models produced similar results. MR-Egger regression analysis suggested the absence of horizontal pleiotropy. The leave-out sensitivity analysis demonstrated that the results were stable.
conclusionThis MR study revealed that T2DM may be associated with a reduced risk of gastric cancer in European and East Asian population.
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