Evidence map›Paper›PMID 40245175›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel.

Changchun Yu, Yandi Zhou, Shuang Yao, Ziyi Wang, Sihao Ye, Rubing Qi, Hai Hu, Keke Liu, Yabo Wu, Tom Lawson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changchun YuSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yandi ZhouSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Shuang YaoSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Ziyi WangSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Sihao YeSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Rubing QiSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Hai HuSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Keke LiuSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yabo WuSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, WC2R2LS, UK.
Tom LawsonSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.
Lu YanSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Yong LiuSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.ORCID https://orcid.org/0000-0001-6932-583X
Wencan WuSchool of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

Funding

Key Research and Development Program of Zhejiang Province 2021C04019National Natural Science Foundation of China U20A20338Natural Science Foundation of Zhejiang Province LQ21H180012
6 · The paper itself

Abstract

This study introduces a novel injectable conductive polymer hydrogel from poly(3,4-ethylenedioxythiophene) (PEDOT). This hydrogel is designed to facilitate the recovery of electrophysiological function in injured optic nerves. The hydrogel can be injected directly at the injury site and spontaneously gel in place. These findings indicate a remarkable restoration of electrophysiological function, with a two to fourfold increase in amplitude (N1-P1 wavelet) of flash visual evoked potentials. Electroretinography results further support that both a-wave and b-wave amplitudes obtained under various adaptation conditions in the PEDOT hydrogel-treated animal models with optic nerve crush are comparable to those in the control group. The visual cliff testing results further supports the enhanced visual functionality after the hydrogel treatment. This improvement signifies enhanced responsiveness to light stimulation and a substantial boost in axonal transmission of visual information. Additionally, the injection of PEDOT hydrogel significantly mitigates the apoptosis of retinal ganglion cells, resulting in a fourfold increase in their survival rate. The ease of preparation and outstanding performance in vivo make it a promising bioengineered material for optic nerve research. This advancement offers new hope for patients with traumatic optic neuropathy, potentially leading to improved treatments and outcomes in optic nerve regeneration.

Indexed as

Bridged Bicyclo Compounds, HeterocyclicHydrogelsNerve RegenerationOptic NerveOptic Nerve InjuriesPolymersAnimalsDisease Models, AnimalElectroretinographyEvoked Potentials, VisualRetinal Ganglion CellsBridged Bicyclo Compounds, HeterocyclicHydrogelspoly(3,4-ethylene dioxythiophene)Polymersnerve regenerationoptic nerve injuriespoly(3,4‐ethylenedioxythiophene) (PEDOT)retinal ganglion cellsvision functionality repair

Identifiers

PMID40245175
PMCPMC12140289

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.