Evidence map›Paper›PMID 40245702›Full record

ArticleRedox biology2025

Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis.

Xunhu Dong, Ying He, Xiaofeng Hu, Jie Wu, Feng Ye, Xiaogang Wang, Yuanpeng Zhao, Guorong Dan, Jiqing Zhao, He Tang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xunhu DongInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Ying HeInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, Army Medical University, Chongqing, 400038, China; Department of Ultrasound, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xiaofeng HuChinese PLA Center for Disease Control and Prevention, Beijing, China.
Jie WuDepartment of Tropical Medicine, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Feng YeInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Xiaogang WangInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Yuanpeng ZhaoInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Guorong DanInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Jiqing ZhaoInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
He TangInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Xiaolu LuInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
Yan SaiInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, China. Electronic address: sai2000cn@tmmu.edu.cn.
Zhongmin ZouInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China. Electronic address: zmzou@tmmu.edu.cn.
Mingliang ChenInstitute of Toxicology, School of Military Preventive Medicine, Army Medical University, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, China. Electronic address: chenml@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrogen mustard (NM) causes severe skin injury that is lack of effective and targeted therapies. Vitamin D3 (VD3) emerges as a promising treatment option for NM-caused dermal toxicity; however, the underlying mechanisms are currently unclear. Herein, we identified that NM markedly promoted ferroptosis by measurement of decreased cell viability, glutathione, glutathione peroxidase 4 and solute carrier family 7 member 11 levels, and increased ROS, lipid ROS, iron/Fe

Indexed as

CholecalciferolFerroptosisRNA, Long NoncodingSkinAnimalsCell SurvivalGlycogen Synthase Kinase 3 betaHumansKeratinocytesMiceNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionCholecalciferolGlycogen Synthase Kinase 3 betaNF-E2-Related Factor 2Proto-Oncogene Proteins c-aktReactive Oxygen SpeciesRNA, Long NoncodingFerroptosisLINC00707Nitrogen mustardNrf2Vitamin D3

Identifiers

PMID40245702
PMCPMC12146658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.