ArticleScientific reports2025
Lithium fine tunes lipid membranes through phospholipid binding.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- MS-based metabolic profiling in serum for bipolar disorder.Metabolic brain disease · 2026Article
- Local Environmental Effects on Light-Driven COACS catalysis · 2026Article
- Ultra-High Performance Liquid Chromatography Mass Spectrometry-based Metabolic Profiling in Urine for Bipolar Disorder with Manic Episode.Noro psikiyatri arsivi · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lithium is commonly prescribed for bipolar disorder due to its proven efficacy on patients. Despite this effectiveness, the molecular mechanisms underlying its action remain poorly understood, as it appears to influence numerous unrelated pathways. We propose that these diverse effects may stem from a specific physicochemical event: the binding of lithium cations to phospholipid headgroups. In model membrane systems enabling direct observation of the lithium effects on lipid bilayers, we reveal that lithium binding stiffens the membrane, subsequently altering membrane protein activities. This mechanical impact of lithium links existing rationales, drawing a way to decipher the complex lithium effect in bipolar disorder (BD). To illustrate this global effect of lithium, we use the example of intracellular trafficking, a ubiquitous mechanism involving membrane reorganization in all organelles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.