ArticleNature human behaviour2025
Multimodal population study reveals the neurobiological underpinnings of chronotype.
Article in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Exposome factors predict the association between sleep health and depression.medRxiv : the preprint server for health sciences · 2026Article
- Individual-Level Associations of Cognition and Personality With Adolescent Mental Health Vary Across Brain and Environmental Profiles.bioRxiv : the preprint server for biology · 2026Article
- Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype.Sleep · 2026Article
- Emotion regulation and depressive symptoms mediate the association between chronotype and suicidality.Acta neuropsychiatrica · 2026Article
- Comprehensive large-scale analyses reveal association between brain structure and cognitive ability during adolescence.Communications biology · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.Nature communications · 2025Article
- School-Based Physical Activity, Cognitive Performance and Circadian Rhythms: Rethinking the Timing of Movement in Education.Children (Basel, Switzerland) · 2025Article
- The Owls Are Not What They Seem: Health, Mood, and Sleep Problems Reported by Morning and Evening Types with Atypical Timing of Weekend Sleep.Clocks & sleep · 2025Article
- Editorial: Environmental risk factors and psychosomatic disorders.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The rapid shifts in society have altered human behavioural patterns, with increased evening activities, increased screen time and changed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with physical and mental health. Night owls often exhibit unhealthier lifestyle habits, are more susceptible to mood disorders and have poorer physical fitness compared with early risers. Although individual differences in chronotype yield varying consequences, their neurobiological underpinnings remain elusive. Here we conducted a pattern-learning analysis with three brain-imaging modalities (grey matter volume, white-matter integrity and functional connectivity) and capitalized on 976 phenotypes in 27,030 UK Biobank participants. The resulting multilevel analysis reveals convergence on the basal ganglia, limbic system, hippocampus and cerebellum. The pattern derived from modelling actigraphy wearables data of daily movement further highlighted these key brain features. Overall, our population-level study comprehensively investigates chronotype, emphasizing its close connections with habit formation, reward processing and emotional regulation.
Indexed as
Identifiers
40246996What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.