ArticleBMC public health2025
Effect of social influence on antiviral therapy behavior among chronic hepatitis B patients with different disease knowledge levels.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07520123 (Union-FAST), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Union-FAST: An Intelligent-Agent Intervention to Increase Antiviral Treatment Uptake in Diagnosed-but-Untreated Hepatitis B Patients：A Multicenter Prospective Study
Who cites it
3 citing papers in PubMed.
- Medication adherence and associated factors in patients with chronic hepatitis B in Zhejiang Province, Eastern China.BMC public health · 2026Article
- Development and Validation of a Social Influence Scale for Antiviral Therapy Behavior of Patients with Chronic Hepatitis B.Risk management and healthcare policy · 2026Article
- Knowledge, attitude, and practice toward antiviral treatment of chronic hepatitis B among patients.Scientific reports · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundChronic hepatitis B (CHB) is a global health challenge with low rates of diagnosis and treatment worldwide. Since social factors and individual cognition significantly influence antiviral therapy adherence in CHB patients, both of which are shaped by patients' understanding of hepatitis B, this study aimed to investigate the effects of social influences on antiviral therapy behavior among CHB patients with different levels of disease knowledge.
methodsFrom March to October 2023, a survey was conducted among CHB patients in Fuqing City, Fujian Province. A self-designed scale was developed based on the attitude-social influence-efficacy (ASE) model, prototype willingness model (PWM), and theory of planned behavior (TPB). Using the mean score as the cutoff point, CHB patients were divided into high and low knowledge levels. Multi-group structural equation modeling (SEM) was used to validate the hypotheses and determine the mechanism of antiviral therapy behavior.
resultsA total of 611 individuals were ultimately included. Multi-group structural equation modeling (SEM) analyses revealed significant differences between patients with high and low disease knowledge levels across three pathways: social support towards self-efficacy (CR = -2.839, P < 0.05), social support towards attitude (CR = 2.142, P < 0.05), and self-efficacy towards behavior (CR = 3.720, P < 0.001). Social support had a stronger influence on self-efficacy in CHB patients with low disease knowledge compared to those with high disease knowledge. Among patients with higher disease knowledge, social support exerted a greater impact on treatment attitudes, while self-efficacy demonstrated a stronger influence on treatment behaviors.
conclusionTo enhance the motivation and adherence of CHB patients to antiviral therapy, healthcare providers could implement tailored health education strategies based on patients' varying levels of knowledge. Additionally, dynamic health goal-setting should be integrated to drive continuous health management. Furthermore, establishing a multi-tiered social support network that incorporates family involvement, community support groups, and healthcare institution collaboration is essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.