ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
In vitro wound healing effects of postbiotics derived from the gut microbiota of long-lived blind mole rats, a model of healthy ageing.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cold-Active Postbiotics from Fermented Food-Derived Lactobacillus fuchuensis H.Y.35 Exhibit Multifunctional In Vitro Bioactivities.Probiotics and antimicrobial proteins · 2026Article
- Article
- Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and Microbial Ecosystem Modulation.Microorganisms · 2026Review
- Postbiotics in Dairy: A Comprehensive Review of Applications and Health Impacts.Current nutrition reports · 2026Review
- Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation.Frontiers in immunology · 2026Review
- Integration of Postbiotics into Adult Diapers:Life (Basel, Switzerland) · 2025Article
- Article
- In vitro wound healing effects of postbiotics derived from the gut microbiota of long-lived blind mole rats, a model of healthy ageing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
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Authors and funding
6 authors.
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Abstract
Chronic wounds represent a global public health burden to patients and healthcare professionals worldwide. Considering the unmet need for safe and effective therapeutic approaches for wound healing, research on discovering new bioactive materials that support all stages of wound healing is gaining importance. In this study, the wound-healing activity of postbiotics obtained from Limosilactobacillus reuteri EIR/Spx-2, isolated from the gut microbiota of long-lived blind mole rats (Nannospalax xanthodon), was investigated. Our results demonstrated that postbiotics exhibited a strong inhibitory effect against important skin pathogens, eliminated their biofilm formation, and downregulated the expression of genes involved in their quorum-sensing regulatory mechanisms. Furthermore, treatment with postbiotics resulted in a significant increase (23.82% ± 2.11%) in L929 fibroblast cell proliferation. Additionally, postbiotics applied on scratched fibroblast monolayer significantly accelerated the re-epithelialization by 66.78% ± 3.74%. The treatment also increased the mRNA expression and protein levels of COL1A1 in the early healing phase. Moreover, the intracellular ROS levels of L929 cells suppressed by H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.