ArticleJournal of cosmetic dermatology2025
Study on Moisturizing Effect of Dendrobium officinale, Sparassis crispa, and Their Compound Extracts.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Comprehensive Review of Bioactive Constituents, Health-Promoting Effects, Processing Technologies, and Industrial Applications ofFoods (Basel, Switzerland) · 2026Review
- Bioactive Polysaccharides from FermentedMolecules (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, natural plants have been widely developed and applied in moisturizing cosmetics. Dendrobium officinale Kimura et Migo (D. officinale) is known as one of the "Nine Immortals" of Chinese herbal medicine, whereas Sparassis crispa (Wulf.) Fr. (S. crispa) is known as the "king of mushrooms"; both of which have excellent biological activity.
aimsTo explore the effects of D. officinale polysaccharide (DOP) with different molecular weights and S. crispa on the expression of moisturizing-related genes and verify the moisturizing performance of their complex.
methodsPCR was carried out to explore the aquaporin 3 (AQP3), hyaluronic acid synthetase1 (HAS1), HAS2, and HAS3 genes expression. Immunofluorescence (IF) analysis was used to test the protein level expression of hyaluronic acid (HA), AQP3, claudin-1, and filaggrin (FLG) influenced by moisturizing composition in a reconstructed epidermis skin model. The ability of samples to resist cell drying damage was evaluated by a cell drying damage model. Furthermore, this study validated the effect of the compositions during their application in cosmetics through tests of skin moisture content, crow's feet, and skin elasticity.
resultsThe results showed that DOP with molecular weights of 100 k-500 kDa (Dalton) had higher effects on AQP3 gene expression compared to that with molecular weights of 10 k-100 kDa and 1 k-10 kDa. Additionally, the extract of S. crispa significantly promoted the expression of HAS1, HAS2, and HAS3 genes, which are genes encoding hyaluronic acid synthesis. In addition, the mRNA and protein expression levels of HA, AQP3, claudin-1, and FLG were significantly increased as a result of the moisturizing composition consisting of DOP (100 k-500 kDa) and S. crispa. The application of the moisturizing composition markedly increased the skin moisture content, improved eye wrinkles, and enhanced skin elasticity.
conclusionsIn summary, our study proved that D. officinale and S. crispa had good moisturizing effects, and as natural plant humectants, they may have broad applications in future moisturizing cosmetics.
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