ArticleMethodsX2025
Evaluating the impact of essential amino acid-rich nutrition intervention on children with autism spectrum disorder: A randomized trial protocol.
Article in MethodsX, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Background: Emerging evidence highlights the role of essential amino acids in brain function and behavior modulation, with deficiencies observed in children with autism. Amino acid supplementation appears to be effective in the autism management. This study aims to assess the effect of plant based amino acid intervention on plasma amino acid profile and behavior aspects in children with autism spectrum disorder. Methods: •The study involves parallel, randomized controlled trial that will include 68 children (age 3-6 years) with mild to moderate ASD. Children will be randomly assigned (1:1) to intervention group receiving nutritional intervention or a control group continuing standard care.•The intervention will be carried out over 16 weeks, with a dosage based on the child's weight and dietary needs.•Primary outcomes include changes in plasma amino acid concentrations Secondary outcomes include changes in Childhood Autism Rating Scale (CARS) and Autism Treatment Evaluation Checklist (ATEC) scores which would be measured pre- and post-intervention. Results: Plasma amino acid levels and behavioral assessments will be compared between the groups to determine the effectiveness of the nutritional intervention in improving symptoms. Conclusion: This trial seeks to establish a sustainable, non-pharmacological approach to managing autism symptoms. Findings would contribute to autism dietary management strategies and the role of essential amino acids in neurodevelopmental health.
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