ReviewCardiovascular endocrinology & metabolism2025
Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches.
Review in Cardiovascular endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.World journal of surgical oncology · 2026Article
- Insulin sensitivity and cardiovascular risk after revascularization: associations with remodeling and long-term outcomes.Frontiers in cardiovascular medicine · 2026Article
- Coronary artery spasm: mechanisms, risk factors, and translational strategies for precision management.Frontiers in cardiovascular medicine · 2026Review
- Cardiovascular Effects of Long-Term Treatment with Enhanced External Counterpulsation in Patients with Ischemic Heart Failure: Randomized, Placebo-Controlled, Open-Label Clinical Trial.Journal of cardiovascular development and disease · 2025Article
- Human CD36: Gene Regulation, Protein Function, and Its Role in Atherosclerosis Pathogenesis.Genes · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) and microvascular ischemia together result in cardiovascular dysfunction by impairing the heart's energy balance. IR in cardiomyocytes disrupts glucose metabolism, leading to energy deficits that can drive cardiac hypertrophy and heart failure. Microvascular ischemia exacerbates these effects by limiting oxygen and nutrient delivery, intensifying oxidative stress, mitochondrial dysfunction, and cell death. IR also reduces the effectiveness of vasodilators like nitroglycerin and sodium nitroprusside, exacerbating endothelial dysfunction and oxidative stress, thus impairing oxygen delivery during ischemia. This combination of IR and microvascular ischemia heightens the risk of left ventricular dysfunction and heart failure. Understanding these interactions is critical for developing targeted therapies to improve outcomes in patients with IR and ischemic heart disease. This study examines the relationship between IR, microvascular ischemia, and myocardial metabolism, with a focus on clinical management and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.