ArticleMedicine and science in sports and exercise2025
Rest Activity Rhythms and Their Association with Cardiorespiratory Fitness and Walking Energetics in Older Adults: Study of Muscle, Mobility, and Aging.
Article in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance, physiology, and determinants of success in IRONMAN® 70.3: A systematic review.PloS one · 2026Pooled it
- Circadian physiology changes with aging: age is just a number, but circadian physiology keeps time.Current opinion in physiology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeIt is recognized that disruptions in circadian behavior, such as with shift work or jet lag, are associated with diminished health. This known relationship implies that people with stronger indices of circadian behavior will exhibit improved physiology. To address the association between rhythmic activity behavior and physiology, we proposed that metrics indicative of "more rhythmic" rest-activity patterns would be associated with better cardiorespiratory fitness and walking energetics in a cohort of older adults.
methodsUsing baseline data from the Study of Muscle, Mobility and Aging ( N = 799, age: 76 ± 5 yr, 58% female), we quantified metrics describing rhythmic aspects of rest-activity behavior (amplitude, robustness, time of peak activity, others) from continuous wrist-worn accelerometry. We used linear models to examine cross-sectional associations between rhythmic metrics with V̇O 2peak and walking energetics (cost-capacity ratio at slow and preferred walking speeds) adjusted for age, sex, race, height, health conditions, and other factors.
resultsMetrics that reflect more rhythmic behavior were associated with V̇O 2peak (higher amplitude: Q1: 18.4 vs Q4: 22.0 mL·kg -1 ·min -1 ; P -trend < 0.001) higher pseudo- F statistic/robustness (Q1: 19.2 vs Q4: 21.3 mL·kg -1 ·min -1 ; P -trend < 0.001), and earlier time of peak activity (Q1 (earliest): 20.9 vs Q4 (latest): 19.2 mL·kg -1 ·min -1 ; P -trend < 0.001). Similar trends were observed with lower cost-capacity ratio at preferred and slow walking speeds (amplitude, pseudo- F statistic, acrophase: P -trend < 0.001 for all).
conclusionsMore rhythmic activity behavior and earlier time of peak activity were associated with better cardiorespiratory fitness and walking energetics. These findings support the framework that rhythmic activity supports healthy physiology. Further investigations are warranted to determine if declines in rhythmicity of human behavior are predictive of disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.