Evidence map›Paper›PMID 40251982›Full record

ArticleAlcohol, clinical & experimental research2025

Insula under the influence: Alcohol-induced changes in resting state functional connectivity.

Adriana K Cushnie, Nicholas J Bush, Landrew S Sevel, Bethany Stennett-Blackmon, Allie Farone, Sara Jo Nixon, Michael E Robinson, Jeff Boissoneault

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adriana K CushnieDepartment of Anesthesiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-3026-9997
Nicholas J BushDepartment of Anesthesiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-8502-3006
Landrew S SevelDepartment of Anesthesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Bethany Stennett-BlackmonDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-3692-0872
Allie FaroneDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Sara Jo NixonDepartment of Psychiatry, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-1179-2851
Michael E RobinsonDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Jeff BoissoneaultDepartment of Anesthesiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2268-6491

Funding

Characterizing the effects of family history of alcoholism on alcohol analgesiaR01AA025337 · NIAAA · UNIVERSITY OF FLORIDA · PI ROBINSON, MICHAEL E · 2018 to 2022
$2.5M
Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
NIAAA NIH HHS R01 AA025337NIH HHS R01AA025337NIH HHS S10 OD021726
6 · The paper itself

Abstract

backgroundThe insular cortex (IC), which includes anterior (AIC) and posterior (PIC) subdivisions, plays a role in numerous functions and behaviors, including chronic alcohol consumption. This study investigated acute alcohol effects on functional connectivity (FC) of the IC in healthy social drinkers. We hypothesized that acute alcohol consumption would significantly disrupt IC resting-state FC (rsFC) with the whole brain and would differentially modulate the rsFC of the AIC and PIC. This study also examined the association of alcohol-induced changes in IC rsFC with subjective intoxication and whether sex and family history of alcohol problems moderate the effect of acute alcohol intake on IC rsFC.

methodsOne hundred and seven healthy social drinkers (25-45 years) completed two counterbalanced laboratory sessions where they consumed either a placebo or alcohol-containing beverage (target breath alcohol concentration 0.08 g/dL), followed by a 9-min resting-state functional magnetic resonance imaging scan. Subjective intoxication was assessed using a visual analog scale from "not at all intoxicated" to "most intoxicated imaginable." Effects of alcohol on IC connectivity were assessed using the CONN toolbox with IC regions of interest (ROIs) defined using the atlas of intrinsic connectivity of homotopic areas (AICHA).

resultsAlcohol intake resulted in widespread changes in rsFC of the IC with other brain regions, including increased rsFC with nodes of the salience network. Alcohol also attenuated differences in rsFC between the AIC and PIC compared with placebo. Sex and family history of alcohol problems did not significantly moderate these effects.

conclusionsAcute alcohol intake altered the rsFC of the IC and its connections to numerous structures. Consistent with prior evidence that alcohol disrupts the brain's functional organization, alcohol intake tended to attenuate differences in the connectivity profiles of AIC and PIC. Additional research is needed to determine how these effects may underlie alcohol's broader neurobehavioral consequences.

Indexed as

Alcohol DrinkingEthanolInsular CortexRestAdultAlcoholic IntoxicationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedEthanolacute alcoholfMRIfunctional connectivityinsular cortex

Identifiers

PMID40251982
PMCPMC12173802

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.