Evidence map›Paper›PMID 40254555›Full record

ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2025

Shikonin attenuates blood-brain barrier injury and oxidative stress in rats with subarachnoid hemorrhage by activating Sirt1/Nrf2/HO-1 signaling.

Guanghu Li, Yang'e Yi, Sheng Qian, Xianping Xu, Hao Min, Jianpeng Wang, Pan Guo, Tingting Yu, Zhiqiang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. What KJPP looks for: guidance from initial editorial screening.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guanghu LiDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Yang'e YiDepartment of Vascular Surgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Sheng QianDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Xianping XuDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Hao MinDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Jianpeng WangDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Pan GuoDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Tingting YuDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.
Zhiqiang ZhangDepartment of Neurosurgery, Affiliated Hospital of Jianghan University, Wuhan 430000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subarachnoid hemorrhage (SAH) is a serious intracranial hemorrhage characterized by acute bleeding into the subarachnoid space. The effects of shikonin, a natural compound from the roots of

Indexed as

AntioxidantsBlood-brain barrierSubarachnoid hemorrhageTight junctionsTraditional Chinese medicine

Identifiers

PMID40254555
PMCPMC12012320

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.