Evidence map›Paper›PMID 40254772›Full record

ReviewESC heart failure2025

Percutaneous mechanical circulatory support for acute right heart failure: A practical approach.

Mario Gramegna, Christophe Vandenbriele, Guido Tavazzi, Mir B Basir, Caroline Bleakley, Mario Iannaccone, Daniel Kretzschmar, Francesco Maisano, Anna Mara Scandroglio, Benedikt Schrage and 9 more

Abstract readReview
In one paragraph

Review in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mario GramegnaCardiac and Cardiac Surgery Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Christophe VandenbrieleDepartment of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; Department of Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Guido TavazziDepartment of Clinical-Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy.
Mir B BasirDivision of Cardiology, Department of Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Caroline BleakleyDepartment of Adult Intensive Care, Royal Brompton & Harefield Hospitals, part of Guys' and St Thomas' Hospital NHS Foundation Trust, London, UK.
Mario IannacconeDivision of Cardiology, Department of Medicine, San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.
Daniel KretzschmarKlinik für Innere Medizin I, Universitaetsklinikum Jena, Am Klinikum 1, Jena, Germany.
Francesco MaisanoDepartment of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Anna Mara ScandroglioCardiac and Cardiac Surgery Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Benedikt SchrageDepartment of Cardiology, University Heart and Vascular Center, Hamburg, Germany.
P Christian SchultzeDepartment of Internal Medicine, Cardiology, Sophien-und Hufeland-Klinikum, Henry-van-de-Velde-Straße 2, Weimar, Germany.
Gregory SerraoThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Matthew TomeyThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Richard TrimlettDepartment of Cardiothoracic Surgery, Royal Brompton & Harefield NHS Foundation Trust, London, UK.
Dirk WestermannDepartment of Cardiology, Arrhythmia Division, Faculty of Medicine, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg im Breisgau, Germany.
Matteo MontorfanoInterventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
George DangasThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Susanna PriceDepartments of Cardiology and Critical Care, Royal Brompton & Harefield Hospitals, part of Guys' and St Thomas' Hospital NHS Foundation Trust, London, UK.
Alaide ChieffoInterventional Cardiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute right heart failure (RHF) represents a critical entity with significant morbidity and mortality. This review examines the role of percutaneous right ventricular assist devices (pRVADs) as a cornerstone of therapy in cases refractory to conventional management. Devices such as the Impella RP and dual-lumen cannulas provide targeted haemodynamic support, with indications in various clinical scenarios, including acute myocardial infarction, post-cardiac surgery, myocarditis, and after left ventricular assist device (LVAD) implantation. Successful implementation requires meticulous haemodynamic assessment, including parameters derived from pulmonary artery catheterization and echocardiography, to guide patient selection, optimize device placement, and monitor therapeutic response. The manuscript highlights contemporary weaning strategies, emphasizing recovery of right ventricular function, stabilization of systemic haemodynamics, and restoration of end-organ perfusion. While no universal protocols exist, this review presents a pragmatic framework informed by available evidence and expert consensus. Furthermore, the potential complications of pRVAD use-ranging from thromboembolism and haemolysis to device-specific issues such as migration and tricuspid valve damage-are discussed alongside preventive and management strategies. Key challenges in RHF management, including the interplay between right and left ventricular function, the impact of pulmonary vascular resistance, and the use of adjunctive pulmonary vasodilators, are addressed. The review underscores the absence of durable right ventricular assist devices and the need for innovation to close this therapeutic gap. Multidisciplinary collaboration among intensivists, cardiologists, and cardiac surgeons is critical to optimizing outcomes. This review provides actionable insights to assist clinicians in navigating the complexities of acute RHF, fostering a tailored and evidence-based approach to this high-risk population.

Indexed as

Heart-Assist DevicesHeart FailureVentricular Function, RightAcute DiseaseHemodynamicsHumansCardiogenic shockECMOImpellapRVAD

Identifiers

PMID40254772
PMCPMC12287799

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.