Evidence map›Paper›PMID 40255037›Full record

ArticleJournal of Alzheimer's disease : JAD2025

The association between pulse wave velocity and cerebrospinal fluid biomarkers for Alzheimer's disease.

Hyena Kim, Ambar Kulshreshtha, Alvaro Alonso, Felicia C Goldstein, Erik Cb Johnson, Matthew E Gold, Arshed A Quyyumi, James J Lah

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyena KimDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0009-0007-0428-7554
Ambar KulshreshthaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0003-4610-1352
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2225-8323
Felicia C GoldsteinDepartment of Neurology, Emory School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-2688-3617
Erik Cb JohnsonDepartment of Neurology, Emory School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-0604-2944
Matthew E GoldEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory School of Medicine, Atlanta, GA, USA.
Arshed A QuyyumiEmory Clinical Cardiovascular Research Institute, Division of Cardiology, Emory School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8166-679X
James J LahDepartment of Neurology, Emory School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-8810-620X

Funding

The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseR01AG070937 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J · 2021 to 2025
$35.2M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Latent Class Methods to Explore the Heterogeneity of Neurodegenerative DiseasesR01AG055634 · NIA · EMORY UNIVERSITY · PI HANFELT, JOHN J · 2017 to 2021
$1.9M
Association of Perceived Stress and CognitionK23AG066931 · NIA · EMORY UNIVERSITY · PI KULSHRESHTHA, AMBAR · 2021 to 2025
$897k
NIA NIH HHS K23 AG066931NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG055634NIA NIH HHS R01 AG070937
6 · The paper itself

Abstract

We examined the association between arterial stiffness using non-invasive pulse wave velocity (PWV) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. We conducted a cross-sectional multivariate logistic regression analysis using established cut-off values for PWV and CSF biomarkers. Of the 739 participants, 69% were female, 84% were White, 12% were Black, and the mean age was 62. After adjustment for potential confounders, participants with high PWV had 94% (OR = 1.94, 95% CI 1.20-3.20) greater odds of AD biomarker positivity for tTau/Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPeptide FragmentsPulse Wave Analysistau ProteinsVascular StiffnessAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer's diseasearterial stiffness‌early detectionepidemiologynon-invasive biomarkerspulse-wave velocityscreening

Identifiers

PMID40255037
PMCPMC12230285

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.