Evidence map›Paper›PMID 40255264›Full record

ArticlePolymer international2025

Diverse reactivity of maleimides in polymer science and beyond.

Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner

Abstract read
In one paragraph

Article in Polymer international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder.
Tayler S HebnerDavidson School of Chemical Engineering, Purdue University.

Funding

Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
NIDDK NIH HHS R01 DK120921
6 · The paper itself

Abstract

Maleimides are remarkably versatile functional groups, capable of participating in homo- and copolymerizations, Diels-Alder and (photo)cycloadditions, Michael additions, and other reactions. Their reactivity has afforded materials ranging from polyimides with high upper service temperatures to hydrogels for regenerative medicine applications. Moreover, maleimides have proven to be an enabling chemistry for pharmaceutical development and bioconjugation via straightforward modification of cysteine residues. To exert spatiotemporal control over reactions with maleimides, multiple approaches have been developed to photocage nucleophiles, dienes, and dipoles. Additionally, further substitution of the maleimide alkene (e.g., mono- and di-halo-, thio-, amino-, and methyl-maleimides, among other substituents) confers tunable reactivity and dynamicity, as well as responsive mechanical and optical properties. In this mini-review, we highlight the diverse functionality of maleimides, underscoring their notable impact in polymer science. This moiety and related heterocycles will play an important role in future innovations in chemistry, biomedical, and materials research.

Indexed as

bioconjugationelastomersheterocycleshydrogelsmaleimidepolymers

Identifiers

PMID40255264
PMCPMC12007691

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.