ArticleFrontiers in physiology2025
Glucose-dependent insulinotropic polypeptide stimulates post-absorptive lipid secretion in the intestine.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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5 authors.
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Abstract
It is increasingly recognized that the intestine can retain a portion of dietary fats for secretion during the post-absorptive state, which has strong implications in metabolic diseases. The regulatory mechanisms of gut lipid storage and release are not well defined. Previous studies showed that the intestine releases locally stored fats in response to several stimulatory cues, such as glucose delivered into the intestinal lumen. It remains unknown how the intestine responds to nutrient signals in this phenomenon. Here we tested the effects of intravenous glucose delivery on intestinal lipid output during the post-absorptive state in mesenteric lymph duct cannulated rats. Compared with intraduodenal glucose delivery, intravenous glucose did not stimulate intestinal lipid output. Intraduodenal glucose was also associated with increases in blood levels of metabolic hormones, among which glucose-dependent insulinotropic peptide (GIP) levels were significantly higher at timepoints corresponding to increased lipid output than in intravenous glucose. Intraperitoneal GIP administration
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