ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The joint and interaction associations of physical activity and sleep with depression: a cohort study.BMC public health · 2026Article
- Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multidimensional self-reported sleep health, cognitive decline, and risk of all-cause dementia: A population-based multi-cohort study.Journal of Alzheimer's disease : JAD · 2026Article
- Systematic Review on the Association Between Sleep and the Risk of Alzheimer's Disease: An Evolutionary Perspective.Evolutionary applications · 2026Review
- Novel sleep metrics derived from chest-worn accelerometers are associated with dementia risk: the Atherosclerosis Risk in Communities neurocognitive study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Association among objective and subjective sleep duration, depressive symptoms and all-cause mortality: the pathways study.BMC psychiatry · 2025Article
- Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Triglyceride-glucose index, renal function, sleep duration, and myocardial infarction: a UK biobank cohort study.Frontiers in nutrition · 2025Article
- Adherence to Life's Essential 8 enhances gut microbiota diversity and cognitive performance.Frontiers in microbiomes · 2025Article
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Abstract
introductionWe investigated whether depression modified the associations between sleep duration and cognitive performance.
methodsWe examined the associations between sleep duration and cognition in 1853 dementia-and-stroke-free participants (mean age 49.8 years, [range 27-85]; 42.7% male). Participants were categorized into four groups: no depressive symptoms, no antidepressants; depressive symptoms without antidepressant use; antidepressant use without depressive symptoms; and depressive symptoms and antidepressant use.
resultsLong sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024). Weaker but significant effects were observed in those without depressive symptoms (-0.18 ± 0.09, p = 0.044). No significant associations were observed in participants using antidepressants without depressive symptoms. DISCUSSION: Associations between sleep duration and cognitive performance are strongest in individuals with depressive symptoms, regardless of antidepressant use. Future research should elucidate underlying mechanisms and temporal relationships. HIGHLIGHTS: Sleeping ≥ 9 hours/night was associated with worse cognitive performance. This association was stronger among those with depression. Long sleepers were more likely to report symptoms of depression. Sleep may be a modifiable risk for cognitive decline in people with depression.
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