ArticleAging clinical and experimental research2025
The association between dietary quality and biological aging: two-mediation analysis.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Dietary diversity, multidimensional gait characteristics, and related biomarkers in older adults: a wearable sensors study.The journal of nutrition, health & aging · 2026Article
- Association of Edentulism With Subsequent Biological Age: A Cohort Study.Journal of clinical periodontology · 2026Article
- Correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism : A matched groups retrospective study.Wiener klinische Wochenschrift · 2026Article
- Impact of biological age versus chronological age on clinical outcomes in patients with atrial fibrillation: insights from the COOL-AF registry.Journal of thrombosis and thrombolysis · 2026Article
- The impact of population aging and rural food markets on the dietary quality of rural residents: a micro case study from China.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsPrevious research has emphasized the firm link between diet and human health. However, the connection between comprehensive dietary patterns and biological aging has not been fully investigated. Our aim was to explore the potential association between dietary quality and delaying aging.
methodsA total of 20,763 participants from the National Health and Nutrition Examination Survey were included in this cross-sectional study. The Mediterranean diet score (MDS), dietary approaches to stop hypertension index (DASHI), and healthy eating index 2020 (HEI2020) were utilized to assess dietary quality. Biological age was determined using the Klemera-Doubal method (KDM) biological age and phenotypic age (Levine's), with the difference between biological age and chronological age representing aging acceleration. Independent relationships between dietary quality and biological aging were analyzed using weighted adjusted linear and logistic regression. Nonlinear trends and robustness of conclusions were examined. A secondary objective was to examine the role of Klotho and γ-glutamyltransferase (GGT) in mediation analyses.
resultsDietary quality exhibited a negative association with biological aging, as evidenced by the interplay between three dietary patterns and two aging measures (The β of the linear regressions were all < 0). Restricted cubic splines confirmed the linear relationship, while subgroup interactions bolstered the stability of the results. Mediation analysis indicated that klotho and GGT partially mediated the association between dietary quality and biological aging (combined proportion mediation: 4.1-8.0%).
conclusionDietary quality is closely associated with biological aging, with anti-aging proteins and oxidative stress potentially serving as underlying mediation mechanisms.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.