ArticleProceedings of the National Academy of Sciences of the United States of America2025
PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes.
Lauren F Uchiyama, Alexander Nguyen, Kevin Qian, Liujuan Cui, Khoi T Pham, Xu Xiao, Yajing Gao, Yuta Shimanaka, Marcus J Tol, Laurent Vergnes and 2 more
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Lauren F UchiyamaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0002-6574-0064
Alexander NguyenDepartment of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Kevin QianDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Liujuan CuiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0001-6186-1558
Khoi T PhamDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Xu XiaoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Yajing GaoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0002-8836-4452
Yuta ShimanakaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Marcus J TolDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Laurent VergnesDepartment of Human Genetics, University of California, Los Angeles, CA 90095.
Karen ReueDepartment of Human Genetics, University of California, Los Angeles, CA 90095.
Peter TontonozDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0003-1259-0477
Funding
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
The impact of estrogen receptor alpha on cardiomyocellular metabolism and healthU54HL170326 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Karen Reue · 2023 to 2026
$7.5M
Lipid storage and utilization in physiology and obesityR01DK136150 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PETER J TONTONOZ · 2023 to 2026
$2.2M
Role of a Novel Methyltransferase in Liver Lipid MetabolismK08DK136706 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Nguyen · 2024 to 2026
$587k
Regulation of hepatic lipid metabolism by novel protein BASICF30DK134050 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI UCHIYAMA, LAUREN F · 2022 to 2025
$186k
Regulation of thermogenesis by the novel brown adipose-specific protein BASICF30DK123986 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QIAN, KEVIN · 2019 to 2023
$168k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK136150NHLBI NIH HHS U54 HL170326NIDDK NIH HHS F30 DK123986NIDDK NIH HHS F30 DK134050NIDDK NIH HHS K08 DK136706NIDDK NIH HHS R01 DK136150NIGMS NIH HHS T32 GM008042
6 · The paper itself
Abstract
Ketogenesis requires fatty acid flux from intracellular (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether interorganelle contact sites regulate this process is unknown. Recent studies have revealed a role for Calsyntenin-3β (CLSTN3β), an endoplasmic reticulum-lipid droplet contact site protein, in the control of lipid utilization in adipose tissue. Here, we show that
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes. · full record | Socratic