Evidence map›Paper›PMID 40258388›Full record

ArticleJournal of biophotonics2025

Endothelial c-Myc and Doxorubicin-Induced Metabolic Alterations: A Multi-Organ Optical Imaging Study.

Parisa Nategh, Mehrnoosh Neghabi, Busenur Ceyhan, Jacqueline F Machi, Homan A Rahbar, Maya S Rodriguez, Aline G Santana, Claudia O Rodrigues, Mahsa Ranji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Parisa NateghBiophotonics Lab, Department of Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida, USA.ORCID 0009-0009-2974-7742
Mehrnoosh NeghabiBiophotonics Lab, Department of Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida, USA.ORCID 0000-0003-1256-4770
Busenur CeyhanBiophotonics Lab, Department of Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida, USA.ORCID 0009-0001-8549-2846
Jacqueline F MachiDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
Homan A RahbarDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
Maya S RodriguezDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
Aline G SantanaDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
Claudia O RodriguesDepartment of Biomedical Science, Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.ORCID 0000-0002-8416-3602
Mahsa RanjiBiophotonics Lab, Department of Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, Florida, USA.ORCID 0000-0002-4185-5676

Funding

NEI NIH HHS R15 EY031533NHLBI NIH HHS R01 HL128536
6 · The paper itself

Abstract

significanceEndothelial c-Myc plays a critical role in redox homeostasis, with its deletion potentially exacerbating oxidative stress, particularly, during chemotherapy.

aimTo assess the metabolic impact of endothelial c-Myc knockout (KO) and Doxorubicin (DOXO) treatment on kidneys, hearts, and livers using 3D optical cryo-imaging. APPROACH: Redox ratios (NADH/FAD) were analyzed in control (CT) and KO mice treated with DOXO or saline to evaluate mitochondrial function and oxidative states.

resultsKO tissues showed significant reductions in redox ratios, indicating an oxidized state, with kidneys exhibiting up to a 51.42% decrease. DOXO treatment further exacerbated oxidative stress in KO tissues, while CT groups demonstrated protective effects.

conclusionsEndothelial c-Myc is crucial for redox balance and protection against chemotherapy-induced oxidative damage, offering insights for targeted therapeutic strategies.

Indexed as

DoxorubicinOptical ImagingOrgan SpecificityProto-Oncogene Proteins c-mycAnimalsKidneyLiverMiceMice, KnockoutOxidation-ReductionOxidative StressDoxorubicinProto-Oncogene Proteins c-myccancerchemotherapy toxicitydoxorubicinendothelial c‐Mycoptical metabolic imagingredox ratio

Identifiers

PMID40258388
PMCPMC12353035

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.