Trial reportLasers in medical science2025
Evaluating efficacy of laser-assisted new attachment procedure and adjunctive low-level laser therapy in treating periodontitis: A single-blind randomized controlled clinical study.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04694222 (Evaluation of Efficacy of LANAP and Adjunctive LLLT Application in the Treatment of Periodontitis), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Efficacy of LANAP and Adjunctive LLLT Application in the Treatment of Periodontitis: A Randomized Controlled Clinical Study
Who cites it
6 citing papers in PubMed.
- 1064 nm Nd:YAG versus 940 nm diode laser-assisted periodontal therapy in stage II periodontitis: a randomized controlled trial.BMC oral health · 2026Trial
- Zinc-Containing Surgical Stents for Soft Tissue Healing: Clinical Case Series and Chair-Side Application.Reports (MDPI) · 2026Article
- Comparison of LED therapy and low laser therapy in post-periodontal healing.Bioinformation · 2026Article
- Use of Laser in Periodontal Tissue Regeneration: A Scoping Review of Clinical and Experimental Evidence.Medicina (Kaunas, Lithuania) · 2025Article
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
- Evaluation of laser-assisted surgery in minimally invasive deciduous teeth extraction.Bioinformation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to evaluate the effectiveness of the laser-assisted new attachment procedure (LANAP) and low-level laser therapy (LLLT) on clinical, biochemical, and radiographic parameters when applied alongside scaling and root planing (SRP).
methodsThe study was designed as a randomized controlled, single-blind, parallel trial involving 68 patients diagnosed with periodontitis. The participants were divided into three groups: Group 1: SRP (control), Group 2: LANAP, and Group 3: LLLT. Clinical measurements, gingival crevicular fluid (GCF) samples, and standard periapical radiographs were obtained pre-treatment and at one- and three-month follow-ups. In GCF, interleukin-1beta (IL-1β), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) were analyzed.
resultsIn moderate (4-6 mm) and deep pockets (≥ 7 mm), laser-treated groups showed a significant reduction in pocket depth (PD) and clinical attachment level (CAL) compared to the control group. However, there were no statistically significant differences in biochemical markers between the groups. Group 2 demonstrated significant bone filling compared to the control group.
conclusionIn deep pockets, laser-treated groups provide additional benefits to SRP. The application of LLLT positively affected recession (REC). TRIAL REGISTRATION NUMBER: NCT04694222 Date of registration: 01/01/2021.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.