ArticleBMC anesthesiology2025
Association between red cell distribution width-to-albumin ratio and short-term mortality in patients with sepsis-associated delirium: a retrospective study from the MIMIC-IV database.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammation and delirium in critically Ill patients: a review.Frontiers in aging neuroscience · 2026Pooled it
- Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury-A Retrospective Cohort Study Based on the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Association between the direct bilirubin to lymphocyte ratio and mortality in patients with necrotizing fasciitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- The prognostic value of red cell distribution width-to-albumin ratio for 28-day mortality in sepsis patients: a multicenter analysis based on the eICU Collaborative Research Database.Frontiers in medicine · 2026Article
- Red cell distribution width to albumin ratio predicts short-term mortality in urosepsis: a dual-cohort study.Frontiers in nutrition · 2026Article
- Hematologic and metabolic indices for predicting 28-day mortality in sepsis patients: a retrospective intensive care cohort study.Frontiers in medicine · 2026Article
- Red cell distribution width to albumin ratio (RAR) as a prognostic marker for mortality in critical care patients: a large-scale retrospective cohort study.European journal of medical research · 2025Article
- Red Cell Distribution Width/Albumin Ratio as a Valuable Marker to Predict Spontaneous Recanalization in Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Cohort Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Abstract
backgroundSepsis-associated delirium (SAD) is a common and severe acute neuropsychiatric manifestation in patients with sepsis, which is associated with increased mortality and lasting cognitive deficits. The red cell distribution width to albumin ratio (RAR) has been recognized as a robust prognostic indicator for adverse outcomes across various diseases. This study aims to investigate the relationship between RAR and short-term mortality in patients with SAD after admission to the intensive care unit (ICU).
methodsThis retrospective cohort study leveraged the MIMIC-IV 3.1 database to analyze the primary outcome of all-cause mortality within 30 days of ICU admission for patients with SAD. According to the receiver operating characteristic(ROC) curve to determine the optimal cut-off point of RAR, SAD patients were divided into low RAR group (RAR < 5.85) and high RAR group (RAR ≧ 5.85). To mitigate potential confounding factors, a 1:1 propensity score matching (PSM) method was implemented. The relationship between RAR and short-term mortality was further assessed using multivariate Cox proportional hazards regression models and Kaplan-Meier (KM) survival curve analyses.
resultsThe study included 4021 patients with SAD. After PSM, 1063 score-matched pairs of patients were generated. Cox proportional hazards models were adjusted for potential confounders, Patients with elevated RAR (≥ 5.85) exhibited a significantly higher 30-day mortality rate compared to those with a lower RAR (< 5.85), with a hazard ratio (HR) of 1.53 (95% CI: 1.35-1.75, P < 0.001). Propensity scores matching analysis corroborated these results, consistently indicating a higher mortality rate in the high RAR group, with an HR of 1.39 (95% CI: 1.19-1.61, P < 0.001).
conclusionsAn Elevated RAR upon ICU admission was independently associated with an increased risk of short-term mortality in patients with SAD.
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