ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Accelerated Epigenetic Aging and Prospective Morbidity and Mortality Among U.S. Veterans.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-traumatic stress disorder moderates the association between BrainAge acceleration and GrimAge acceleration.Neurobiology of aging · 2026Pooled it
- Revisiting the relationship between cardiorespiratory fitness and biological aging: insights from DunedinPACE analysis.GeroScience · 2026Article
- Using a Biomarker of Biological Aging to Predict Incident Cardiometabolic Disease.Journal of the American Heart Association · 2026Article
- Interpersonal adversity and health across the life course.Current opinion in psychology · 2026Review
- Comparing fourteen consensus biomarkers of aging: epigenetic pace of aging as the strongest predictor of mortality in BASE-II.Biomarker research · 2026Article
- The role of health behaviors in links between stress and epigenetic aging.Brain, behavior, & immunity - health · 2026Article
- Dietary pattern modifies associations between dietary factors and pace of epigenetic aging.Frontiers in nutrition · 2026Article
- Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.Epigenomics · 2025Article
- Dissecting epigenetic age acceleration in amyotrophic lateral sclerosis.Epigenomics · 2025Article
- Association between the psychological frailty index and stroke: a cohort study from CHARLS.Scientific reports · 2025Article
- Tracking Epigenetic Biomarkers of Health and Aging During the Initial Year of Gender-Affirming Hormone Therapy.The Yale journal of biology and medicine · 2025Article
- Accelerated biological aging and midlife frailty among U.S. military veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Posttraumatic Stress Disorder, Obesity, and Epigenetic Aging: A Replication Study in 1828 Veterans.Biopsychosocial science and medicineArticle
- Traumatic Brain Injury and Accelerated Epigenetic Aging Among Post-9/11 Veterans.The Journal of head trauma rehabilitationArticle
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Authors and funding
19 authors.
Funding
Abstract
backgroundEpigenetic aging measures have promise as surrogate health outcomes in randomized control trials and observational cohort studies. The value of these measures, however, will reflect the extent to which they are associated with prospective health outcomes in real-world medical settings.
methodsUsing data from 2 216 post-9/11 veterans from the VISN 6 MIRECC's Post-Deployment Mental Health Study, we examined whether accelerated epigenetic aging, assessed by DunedinPACE, was associated with prospective chronic disease morbidity, predicted healthcare costs, and mortality over an average of 13.1 years of electronic health record follow-up.
resultsVeterans with faster DunedinPACE aging scores developed more chronic disease over the subsequent 5 years (RR, 1.25; 95% CI, 1.14-1.36), 10 years (RR, 1.31; 95% CI, 1.21-1.40), and 15 years (RR, 1.36; 95% CI, 1.22-1.52). Faster aging scores were also associated with increases in predicted healthcare costs over the next 5 years (β = 0.08; 95% CI, 0.03-0.13), 10 years (β = 0.23, 95% CI, 0.15-0.31), and 15 years (β = 0.21; 95% CI, 0.11-0.30). Faster DunedinPACE aging scores were associated with greater risk for incident myocardial infarction (84%), stroke (38%), diabetes (56%), cancer (25%), liver disease (44%), and renal disease (34%), as well as greater risk of mortality due to all-causes (38%) and chronic disease (74%). These results remained when adjusting for demographic, biomarker, and smoking covariates.
conclusionsOur findings suggest DunedinPACE is a biomarker of accelerated aging that is prospectively associated with chronic disease morbidity and mortality, as assessed using health records from an integrated healthcare system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.