Evidence map›Paper›PMID 40259586›Full record

ReviewCurrent organic synthesis2025

3-Acetyl Indole in the Synthesis of Natural Bioactive Compounds.

Eslam R El-Sawy, Mohamed S Abdel-Aziz, Gilbert Kirsch

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current organic synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eslam R El-SawyChemistry of Natural Compounds Department, National Research Centre, Dokki, 12622, Giza, Egypt.ORCID 0000-0002-7505-3356
Mohamed S Abdel-AzizMicrobial Chemistry Department, Biotechnology Research Institute, National Research Centre, Dokki, 12622, Giza, Egypt.ORCID 0000-0001-9151-5920
Gilbert KirschLaboratoire Lorrain de Chimie Moléculaire (L.2.C.M.), Université de Lorraine, Metz, 57050, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products, with their various sources from plants, marine organisms, and microorganisms, are considered a key source and inspiration for medicines and continue to be so. Indole alkaloids are a class of alkaloids and represent a large subunit of natural products. Indole alkaloids of biological importance are numerous and cover a wide range of pharmaceutical applications, including anticancer, antiviral, antimicrobial, anti-inflammatory, and antioxidant. Obtaining natural, biologically active indole compounds involves isolating them from their natural sources or preparing them synthetically. 3-Substituted indoles represent an emerging structural class of marine alkaloids based on their high degree of biological activity. 3-Acetyl indole is an important core used as a starting material for synthesizing many bioactive indole alkaloids. (5-Indole)oxazole alkaloids, β-carboline alkaloids, bis-indole alkaloids, chuangxinmycin, meridianine, and (±) indolemycin are the most important indole alkaloids that are prepared starting from 3-acety indole. The present review provides comprehensive information on the structures and the synthesis of bioactive indole alkaloids utilizing 3-acetyl indole and its derivatives as starting compounds. Additionally, it also spotlights the diverse biological activities of these compounds.

Indexed as

Biological ProductsIndole AlkaloidsIndolesMolecular StructureBiological ProductsIndole AlkaloidsIndoles3-acetyl indolebiological activity.bis-indolechuangxinmycinindole alkaloidsindolmycinmeridianinsβ-carboline

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.