Evidence map›Paper›PMID 40259744›Full record

ArticleeLife2025

In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins.

Shinichi Kawaguchi, Xin Xu, Takashi Soga, Kenta Yamaguchi, Ryuuya Kawasaki, Ryota Shimouchi, Susumu Date, Toshie Kai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Sketching microprotein portraits.Protein science : a publication of the Protein Society · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shinichi Kawaguchi *Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-7832-1918
Xin Xu *Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Takashi SogaD3 Center, Osaka University, Osaka, Japan.
Kenta YamaguchiNEC Solution Innovators, Ltd., Tokyo, Japan.
Ryuuya KawasakiNEC Solution Innovators, Ltd., Tokyo, Japan.
Ryota ShimouchiGraduate School of Information Science and Technology, Osaka University, Osaka, Japan.
Susumu DateD3 Center, Osaka University, Osaka, Japan.
Toshie KaiGraduate School of Frontier Biosciences, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8675-8469

Funding

Ministry of Education, Culture, Sports, Science and Technology 21H05275Osaka University Na22990007Takeda Science Foundation J191503009
6 · The paper itself

Abstract

Protein-protein interactions are fundamental to understanding the molecular functions and regulation of proteins. Despite the availability of extensive databases, many interactions remain uncharacterized due to the labor-intensive nature of experimental validation. In this study, we utilized the AlphaFold2 program to predict interactions among proteins localized in the nuage, a germline-specific non-membrane organelle essential for piRNA biogenesis in

Indexed as

Computational BiologyDrosophila melanogasterDrosophila ProteinsProtein Interaction MappingRNA, Small InterferingAnimalsComputer SimulationPiwi-Interacting RNAProtein BindingDrosophila ProteinsPiwi-Interacting RNARNA, Small InterferingAlphaFold2biochemistrychemical biologycomputational biologyD. melanogasterin silico screeningnuagepiRNAprotein–protein interactionsystems biology

Identifiers

PMID40259744
PMCPMC12014135

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.