Evidence map›Paper›PMID 40260131›Full record

ArticleNature reviews bioengineering2025

Imaging-guided precision hyperthermia with magnetic nanoparticles.

Ali Shakeri-Zadeh, Jeff W M Bulte

Abstract read
In one paragraph

Article in Nature reviews bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. High-Temperature Magnetic Field Mapping Using a Single-Crystal Diamond MEMS Resonator Array.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. [Research progress of photoacoustic imaging in diagnosis of limb lymphedema].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Magnetic iron oxide (FeRSC advances · 2026
    Article
  13. Luminescent FeChembiochem : a European journal of chemical biology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ali Shakeri-ZadehThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2847-9223
Jeff W M BulteThe Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1202-1610

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
NCI NIH HHS R01 CA257557NIBIB NIH HHS P41 EB024495NIH HHS S10 OD026740
6 · The paper itself

Abstract

Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic techniques. In vivo imaging techniques based on the detection of magnetic nanoparticles inside the body include magnetic resonance imaging (MRI), magnetic particle imaging (MPI), magneto-motive ultrasonography (MMUS) and magneto-photoacoustic imaging (MPAI). Preclinical data indicate that the conditions required to heat up magnetic nanoparticles, including energy considerations, particle modifications, localization and exposure time, can be dynamically modulated during a single treatment procedure by monitoring imaging data acquired from the same magnetic nanoparticles. This Review explores the potential use of magnetic-nanoparticle-mediated imaging techniques combined with magnetic fluid hyperthermia (MFH) to selectively and precisely heat tumour locations while avoiding damage to surrounding healthy tissue. Imaging-guided MFH could provide individualized treatment plans based on information about the biodistribution of magnetic nanoparticles within the tumour and adjacent organs, as well as the volumetric distribution of the thermal dose. Requirements for the clinical translation of MFH-enabled magnetic imaging techniques are also discussed - the development of magnetic nanoparticle formulations with a favourable biosafety profile, optimal magnetic heating properties and maximal magnetic imaging signals; and the integration of magnetic imaging and heating hardware into a single platform.

Identifiers

PMID40260131
PMCPMC12011369

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.