ArticleNeuropsychiatric disease and treatment2025
Clinical Efficacy of Acupuncture Combined with Escitalopram Oxalate in the Treatment of Mild-to-Moderate Post-Stroke Depression.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Acupuncture combined with antidepressants for mild-to-moderate depressive disorders: a systematic review with meta-analysis and trial sequential analysis.Frontiers in neurology · 2025Pooled it
- Early emotional interventions for post-stroke functional prognosis: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Central Neurobiological Mechanisms of Acupuncture in Post-Stroke Depression: Multi-Target and Network-Based Regulation.Neuropsychiatric disease and treatment · 2026Review
- Research Progress on the Pathogenesis of Post-Stroke Depression.ACS omega · 2025Review
- Acupuncture and Moxibustion for Poststroke Depression: Systematic Review.Interactive journal of medical research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This analysis observed the clinical effect of acupuncture combined with Escitalopram oxalate in the treatment of mild to moderate post-stroke depression (PSD). Methods: This was a retrospective study of 1:1 matching design. A total of 96 cases of mild to moderate PSD patients were enrolled and divided into 48 cases each in the control group and the observation group. The control group received treatment with Escitalopram oxalate tablets. The observation group received acupuncture combined with Escitalopram Oxalate, both for a duration of 8 weeks. Comparisons were performed in regard clinical efficacy, 17-Item Hamilton Rating Scale for Depression (HAMD-17), National Institutes of Health Stroke Scale (NIHSS), Pittsburgh Sleep Quality Index (PSQI), Barthel Index, neurotransmitters (5-hydroxytryptamine [5-HT], norepinephrine [NE], and dopamine [DA]), and liver function (alanine aminotransferase [ALT], aspartate transaminase [AST], direct bilirubin [DBIL], and total bilirubin [TBIL]). The Side Effect Rating Scale (SERS) scores at weekends 4 and 8 of treatment were counted. Results: The total effective rate was 91.67% (44/48) higher for the observation group than 75.00% (36/48) for the control group ( Conclusion: Combining acupuncture with Escitalopram oxalate proves to be effective and safe for treating mild-to-moderate PSD, significantly alleviating depression, and enhancing neurological function, sleep quality, and quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.