Evidence map›Paper›PMID 40260473›Full record

SynthesisHead & neck2025

Application of Biomaterials for the Prevention of Pharyngeal Fistulae: A Systematic Review.

Emilien Chabrillac, Audrey Tourrette, Michel Habib, Marilys Blanchy, Céline Des Courtils, Grégoire D'Andréa, Philippe Lavalle, Agnès Dupret-Bories

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emilien ChabrillacDepartment of Surgery, University Cancer Institute of Toulouse, Toulouse, France.ORCID 0000-0003-4113-2846
Audrey TourretteCIRIMAT, Université Toulouse 3 Paul Sabatier, Toulouse INP, CNRS, Université de Toulouse, Toulouse, France.
Michel HabibCIRIMAT, Université Toulouse 3 Paul Sabatier, Toulouse INP, CNRS, Université de Toulouse, Toulouse, France.
Marilys BlanchyRescoll, Pessac, France.
Céline Des CourtilsLaboratoires Brothier, Nanterre, France.
Grégoire D'AndréaInstitut Universitaire de la Face et du Cou, Head and Neck Departement, Nice University Hospital, Nice, France.
Philippe LavalleInserm UMR_S 1121, CNRS EMR 7003, Université de Strasbourg, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Strasbourg, France.
Agnès Dupret-BoriesDepartment of Surgery, University Cancer Institute of Toulouse, Toulouse, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery.

methodsThis systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.

resultsA total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (n = 15) or to replace a mucosal defect and guide secondary healing (n = 4). Most studies evaluated commercialized biomaterials (n = 11) rather than experimental devices (n = 5) or platelet-derived autologous medical devices (n = 4).

conclusionThere are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.

Indexed as

Biocompatible MaterialsCutaneous FistulaPharyngeal DiseasesPostoperative ComplicationsAnimalsHumansBiocompatible Materialsbiomaterialfistulapharyngeal leaksealanttotal laryngectomy

Identifiers

PMID40260473
PMCPMC12146823

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.