ArticleBiology open2025
Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon.
Article in Biology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- A short-lived fish with long-lasting effects: hallmarks of aging inFrontiers in aging · 2025Review
- Single-cell sequencing unveils the impact of aging on the progenitor cell diversity in the telencephalon of the female killifish N. furzeri.Aging cell · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
The African turquoise killifish (Nothobranchius furzeri) is becoming a favorable model for neurobiological research. The combination of a short lifespan and a declining neuroregenerative capacity upon aging makes it ideally suited for research on brain aging and regeneration. A remarkable cellular diversity makes up the young-adult killifish telencephalon, characterized by highly proliferative non-glial progenitors and spatially distinct radial glia subtypes. In contrast to a relatively slow embryonic development, hatching is followed by a period of accelerated growth, in which the brain experiences a period of rapid expansion and maturation. In this study, we quantified the growth progression and maturation of the killifish telencephalon during early post-embryonic development. We discovered that, similar to in zebrafish, neuro-epithelial cells abut the neurogenic niches from early life onwards. Spatial data revealed qualitative and quantitative differences along the anterior-posterior axis and between pallial and subpallial regions in terms of growth pace. We confirmed generation of GABAergic neurons from the subpallial neurogenic niche and glutamatergic neurons from two pallial niches. Our data further showed a more widespread appearance of inhibitory neurons at hatching compared to in zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.