Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension.

Yunfeng Fang, Jingwen Yue, Min Zhang, Li Jiang

Abstract read

In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunfeng FangDepartment of Cardiology, TONG REN Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.

Jingwen YueCardiovascular Disease Research Laboratory, TONG REN Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.

Min ZhangCardiovascular Disease Research Laboratory, TONG REN Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. zm19821982@hotmail.com.

Li JiangCardiovascular Disease Research Laboratory, TONG REN Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. Jiangli@shtrhospital.com.

Funding

National Natural Science Foundation of China 82170450

6 · The paper itself

Abstract

This study investigated the association between serum small peptides and arteriosclerosis (AS) in hypertensive patients. Sixty hypertensive patients (with and without AS) and 30 healthy individuals were enrolled. Untargeted metabolomics identified 120 peptides in AS patients, 136 in hypertensive patients, and 59 shared peptides. LASSO regression identified key peptides differentiating hypertensive patients with AS from those without. Peptides like Thr-Ile, Phe-Asp-Lys, and Lys-Ile-Val-Lys were upregulated in AS, while others like Gln-Glu and Lys-Lys were higher in non-AS patients. The diagnostic model showed AUCs of 0.896 for AS and 0.909 for non-AS. Elevated levels of Lys-Ile-Val-Lys and Phe-Asp-Lys were linked to increased carotid intima-media thickness, indicating higher AS risk.

Indexed as

ArteriosclerosisBlood PressureCarotid Artery DiseasesEssential HypertensionMetabolomicsPeptidesAdultAgedBiomarkersCarotid Intima-Media ThicknessCase-Control StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsBiomarkersPeptidesArteriosclerosisCarotid intima-media thicknessHypertensionSmall peptidesUntargeted metabolomics

Identifiers

PMID40261542

DOI10.1007/s12265-025-10616-z

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.