Evidence map›Paper›PMID 40261813›Full record

ArticleeLife2025

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

Linsey Peters, Leonida Rakateli, Rosanna Huchzermeier, Andrea Bonnin-Marquez, Sanne L Maas, Cheng Lin, Alexander Jans, Yana Geng, Alan Gorter, Marion Gijbels and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Linsey Peters *Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Leonida Rakateli *Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Rosanna HuchzermeierInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Andrea Bonnin-MarquezInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Sanne L MaasInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Cheng LinDepartment of Rheumatology and Shanghai Institute of Rheumatology, Renji, Shanghai, China.
Alexander JansDepartment of Rheumatology and Shanghai Institute of Rheumatology, Renji, Shanghai, China.
Yana GengDepartment of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Alan GorterDepartment of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Marion GijbelsDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.
Sander RensenDepartment of Surgery, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.
Peter OlingaDepartment of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Tim HendrikxDepartment of Laboratory Medicine, Medical University Vienna, Vienna, Austria.
Marcin KrawczykDepartment of Gastroenterology, Hepatology and Transplant Medicine, Medical Faculty, University of Duisburg, Essen, Germany.
Malvina BrisboisDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Joachim JankowskiInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Kiril BidzhekovInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Munich, Germany.
Christian WeberInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Munich, Germany.
Erik A L BiessenInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
Ronit Shiri-SverdlovDepartment of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, Netherlands.ORCID 0000-0002-6736-7814
Tom HoubenDepartment of Genetics and Cell Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, Netherlands.
Yvonne DöringInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Munich, Germany.
Matthias BartneckDepartment of Rheumatology and Shanghai Institute of Rheumatology, Renji, Shanghai, China.
Emiel van der VorstInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-5771-6278

Funding

Austrian Science Fund 10.55776/P36774Austrian Science Fund ZK81-BBundesministerium für Bildung und Forschung 16LW0143 Mamma-ExplantBundesministerium für Bildung und Forschung Cluster4Future: Cluster for Nucleic Acid Therapeutics Munich (CNATM)China Scholarship Council CSC stipend 202008320329Corona-Stiftung S199/10084/2021COST Action Mye-InfoBank 476 CA20117Fritz Thyssen Stiftung 10.20.2.043MNGerman Research Foundation BA6226/2-1German Research Foundation BA6226/2-3German Research Foundation CRC 1382, Project-ID: 403224013German Research Foundation DFG SFB/TRR219, Project ID 322900939, Subproject M07German Research Foundation SFB TRR219, Project ID 322900939NWO-ZonMw Veni 91619053RWTH Aachen University ERS grant G:(DE-82)EXS-SF-OPSF732State of NRW ZM-1-27B NovoKolonSwiss National Science Foundation Project ID 310030-197655Wilhelm Sander Foundation 2018.129.1ZonMw Meer Kennis met Minder Dieren 114022505
6 · The paper itself

Abstract

The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b (

Indexed as

Fatty LiverMicroRNAsNanoparticlesAnimalsApolipoproteins EDisease Models, AnimalHumansLipid MetabolismLiposomesLiverMaleMiceMice, KnockoutApolipoproteins ELipid NanoparticlesLiposomesMicroRNAsMirn26 microRNA, mousehepatic inflammationhumanimmunologyinflammationlipid nanoparticlesmetabolic dysfunction-associated steatohepatitismicroRNAsmouse

Identifiers

PMID40261813
PMCPMC12014130

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.