ReviewCurrent opinion in neurobiology2025
Mapping and decoding neuropeptide signaling networks in nervous system function.
Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Organization of neuropeptide systems in the human brain.Nature neuroscience · 2026Article
- Dense and distributed neuropeptide network in the nerve net of Hydra vulgaris.PLoS computational biology · 2026Article
- Autocrine feedback maintains homeostatic neuropeptide expression in a peptidergic hub neuron.bioRxiv : the preprint server for biology · 2026Article
- Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.Frontiers in insect science · 2026Article
- Four neurons pattern brain-wide developmental activity through neuropeptide signaling.bioRxiv : the preprint server for biology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptides are widespread signaling molecules that are central to brain function in all animals. Recent advances in profiling their expression across neural circuits, in conjunction with detailed biochemical characterization of their interactions with receptors, have made it feasible to build brain-wide maps of neuropeptide signaling. Here, we discuss how recent reconstructions of neuropeptide signaling networks, from mammalian brain regions to nervous system-wide maps in C. elegans, reveal conserved organizational features of neuropeptidergic networks. Furthermore, we review recent technical breakthroughs in in vivo sensors for peptide release, receptor binding, and intracellular signaling that bring a mechanistic understanding of neuropeptide networks within experimental reach. Finally, we describe how the architecture of neuropeptide signaling networks can change throughout evolution or even the lifetime of individuals, which highlights the complexities that must be considered to understand how these molecules modulate circuit activity and behavior across different contexts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.