Evidence map›Paper›PMID 40263271›Full record

ArticleNature communications2025

Structure of a lasso peptide bound ET

Wataru Shihoya, Hiroaki Akasaka, Peter A Jordan, Anna Lechner, Bethany K Okada, Gabriella Costa Machado da Cruz, Fumiya K Sano, Tatsuki Tanaka, Ryo Kawahara, Rajan Chaudhari and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  2. De novo Folding Mechanisms of Lasso Peptides.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wataru Shihoya *Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. wtrshh9@gmail.com.ORCID http://orcid.org/0000-0003-4813-5740
Hiroaki Akasaka *Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2118-0912
Peter A JordanLassogen Inc., San Diego, CA, USA.
Anna LechnerLassogen Inc., San Diego, CA, USA.
Bethany K OkadaLassogen Inc., San Diego, CA, USA.
Gabriella Costa Machado da CruzLassogen Inc., San Diego, CA, USA.
Fumiya K SanoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8965-788X
Tatsuki TanakaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5728-7573
Ryo KawaharaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Rajan ChaudhariResearch Informatics, Eurofins Panlabs, Inc., Saint Charles, MO, USA.
Hiroko MasamuneLassogen Inc., San Diego, CA, USA.
Mark J BurkLassogen Inc., San Diego, CA, USA. mburk@lassogen.com.ORCID http://orcid.org/0000-0002-2045-2691
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0003-1813-7008

Funding

Japan Agency for Medical Research and Development (AMED) JP233fa627001Japan Agency for Medical Research and Development (AMED) JP23ama121002Japan Agency for Medical Research and Development (AMED) JP23ama121012MEXT | Japan Society for the Promotion of Science (JSPS) 21H05037
6 · The paper itself

Abstract

Lasso peptides exhibit a unique lariat-like knotted structure imparting exceptional stability and thus show promise as therapeutic agents that target cell-surface receptors. One such receptor is the human endothelin type B receptor (ET

Indexed as

PeptidesReceptor, Endothelin BReceptors, G-Protein-CoupledCryoelectron MicroscopyDrug Inverse AgonismHEK293 CellsHumansModels, MolecularProtein BindingProtein ConformationStructure-Activity RelationshipEDNRB protein, humanPeptidesReceptor, Endothelin BReceptors, G-Protein-Coupled

Identifiers

PMID40263271
PMCPMC12015262

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.