Evidence map›Paper›PMID 40263344›Full record

ArticleScientific reports2025

Shenfu injection alleviates lipopolysaccharide-induced liver injury in septic mice.

Bai-Tao Lu, Ya-Jun Wang, Lei Wang, Di Wu, Yi-Lu Lin, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Hui-Ying Liu, Huan Meng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hydrogen gas (HFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bai-Tao Lu *Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China.
Ya-Jun Wang *Department of Pediatrics, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, 150027, Heilongjiang Province, China.
Lei Wang *Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China.
Di Wu *Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Harbin, 150027, Heilongjiang Province, China.
Yi-Lu LinDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Harbin, 150027, Heilongjiang Province, China.
Jia-Xi XuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China.
Jia-Ning ZhangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China.
Bo-Wen LiuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China.
Hui-Ying LiuDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Harbin, 150027, Heilongjiang Province, China.
Huan MengDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Harbin, 150027, Heilongjiang Province, China.
Yang GaoDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, No.998 Aiying Road, Harbin, 150027, Heilongjiang Province, China. gaoyang0312@126.com.
Hong-Liang WangDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, No.246 Xuefu Road, Harbin, 150086, Heilongjiang Province, China. icuwanghongliang@163.com.
Kai KangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Harbin, 150001, Heilongjiang Province, China. janekk79@126.com.

Funding

the Special Fund for Clinical Research of Wu Jie-Ping Medical Foundation No.320.6750.2022-02-16
6 · The paper itself

Abstract

Shenfu injection (SFI) is a traditional Chinese medicine (TCM) for treating sepsis. The purpose of this study was to evaluate the protective effect of SFI on lipopolysaccharide (LPS)-induced liver injury in septic mice. The results showed that SFI intervention reduced liver/body weight and significantly improved the survival rate of septic mice. SFI could relieve the apoptosis of liver cells and ameliorate liver function in LPS-induced septic mice. SFI also diminished the serum and liver levels of the inflammatory factors IL-1β, IL-6, IL-18, IL-12, and TNF-α in a dose-dependent manner. SFI enhanced the mitochondrial membrane potential and alleviated the mitochondrial damage of liver in septic mice. Western blot revealed that the phosphorylation levels of IκB and NF-κB p65 increased significantly in the liver of LPS-induced septic mice. After SFI intervention, the phosphorylation levels of IκB and NF-κB p65 gradually recovered, especially at high concentration. SFI treatment reduced nuclear transduction, thus reducing transcriptional activity, which indicated that NF-κB p65 signal pathway might contribute to the anti-inflammatory and anti-apoptotic activities of SFI in the liver of LPS-induced septic mice. In addition, the metabolic profile of liver tissue in the model group was different from that in the control group, and SFI significantly regulated liver purine metabolism. These valuable findings suggested that SFI could improve mitochondrial function and mitigate inflammation and apoptosis, and thus alleviate LPS-induced liver injury in septic mice. SFI may be a promising drug to treat septic liver injury.

Indexed as

Chemical and Drug Induced Liver InjuryDrugs, Chinese HerbalLipopolysaccharidesSepsisAnimalsApoptosisCytokinesDisease Models, AnimalLiverMaleMembrane Potential, MitochondrialMicePhosphorylationSignal TransductionTranscription Factor RelACytokinesDrugs, Chinese HerbalLipopolysaccharidesShen-FuTranscription Factor RelAApoptosisInflammationLiver injuryPurine metabolismSepsisShenfu injectionTraditional Chinese medicine

Identifiers

PMID40263344
PMCPMC12015584

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.