Evidence map›Paper›PMID 40263458›Full record

ArticleCommunications biology2025

GABA and astrocytic cholesterol determine the lipid environment of GABA

Zixuan Yuan, Mahmud Arif Pavel, Scott B Hansen

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Direct modulation of human GABA-A αFrontiers in neuroscience · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zixuan YuanDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA.ORCID http://orcid.org/0000-0003-0665-5086
Mahmud Arif PavelDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA.
Scott B HansenDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, 33458, USA. shansen@cimrbj.ac.cn.ORCID http://orcid.org/0000-0003-0086-9753

Funding

The role of lipid raft disruption in the activation of TREK-1 channels by anestheticsR01NS112534 · NINDS · UNIVERSITY OF FLORIDA · PI HANSEN, SCOTT B · 2019 to 2023
$2.2M
NINDS NIH HHS R01 NS112534U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RO1 NS112534
6 · The paper itself

Abstract

The γ-aminobutyric acid (GABA) type A receptor (GABA

Indexed as

AstrocytesCerebral CortexCholesterolgamma-Aminobutyric AcidNeuronsReceptors, GABA-AAlzheimer DiseaseAnimalsCells, CulturedMembrane MicrodomainsMiceMice, Inbred C57BLPhosphatidylinositol 4,5-DiphosphateCholesterolgamma-Aminobutyric AcidPhosphatidylinositol 4,5-DiphosphateReceptors, GABA-A

Identifiers

PMID40263458
PMCPMC12015214

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.