ArticleScientific reports2025
Neutrophils induce astrocytic AQP4 expression via IL-1α and TNF, contributing to cerebral oedema in ischaemic stroke rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Thromboembolic ischemic stroke induces neutrophil recruitment and matrix metalloproteinase-9 release to enhance ischemic brain injury.Research and practice in thrombosis and haemostasis · 2026Article
- Extracellular vesicles: Revolutionizing targeted therapy for ischemic stroke.Acta pharmaceutica Sinica. B · 2026Review
- Predicting early neurological deterioration in acute branch atheromatous disease without reperfusion therapy: a machine learning model.Frontiers in neuroscience · 2026Article
- Article
- Association between the stress hyperglycemia ratio and all-cause mortality in patients with hemorrhagic stroke: a retrospective analysis based on MIMIC-IV database.Frontiers in neurology · 2025Article
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6 authors.
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Abstract
During the acute phase (1-3 days) of cerebral infarction, neutrophils and macrophages accumulate at the infarction site, inducing inflammation and cerebral oedema. However, the role of neutrophils in oedema formation after ischaemic stroke remains unclear. This study examined neutrophil involvement in cerebral oedema using a transient middle cerebral artery occlusion (tMCAO) rat model, primary cultured neutrophils, and astrocytes. Brain specimens were stained with myeloperoxidase (MPO) and lymphocyte antigen 6 complexes, locus G (Ly6G), and the number of MPO
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Registered trials
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