ArticleScientific reports2025
Exploring the mechanisms of Chaige Kangyi Recipe in treating recurrent pregnancy loss with insulin resistance.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Gu Ben An Tai decoction combined with dydrogesterone for early threatened abortion secondary to spleen and kidney deficiency: a retrospective observational study.Contraception and reproductive medicine · 2026Article
- From Microbiota to Defense: The Preventive Effect and Mechanism of Total Flavonoids from Sea Buckthorn Leaves in DSS-Induced Colitis.Nutrients · 2026Article
- Modes of action of traditional Chinese medicine for diabetic infertility: from molecular pathways to clinical evidence.American journal of clinical and experimental immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Chinese herbal medicine effectively treats recurrent pregnancy loss, though its mechanism is unclear. This study used RStudio 4.3.0 to collect successful cases for cluster analysis, identifying medication patterns and core formulas, and further researching key prescriptions. The prescription is frequently used for recurrent abortion patients with insulin resistance. UPLC-QTOF-MS identified components, and network pharmacology explored key prescription targets in recurrent abortion with insulin resistance, validated by molecular docking and in vitro experiments. Traditional Chinese medicine treatment for 177 recurrent abortion cases and 640 prescriptions was analysed using RStudio 4.3.0 to identify medication patterns. Chaige Kangyi Recipe (CGKYR) active components and targets were obtained from TCMNPAS, and a herb-ingredient-target gene network was constructed using Cytoscape 3.7.2. GeneCards provided RSA target genes, and Cytoscape visualised a drug-disease target PPI network. Metascape software performed GO and KEGG enrichment analyses. UHPLC-MS/MS identified active compounds in core prescriptions, and molecular docking evaluated the therapeutic effects and mechanisms of major chemical components on key targets. Key prescriptions were derived from RStudio 4.3.0 cluster analysis of the Chaige Kangyi Recipe (CGKYR), commonly used for recurrent miscarriages with insulin resistance. Sixty-seven active ingredients were identified via UPLC-QTOF-MS. Network pharmacology revealed 179 target genes related to CGKYR's effects on recurrent miscarriage with insulin resistance. PPI analysis indicated IL-6, AKT1, STAT3, and INS as potential targets. Molecular docking demonstrated strong binding activity of four compounds with IL-6.CCK-8 assays showed CGKYR promoted HDSC proliferation dose-dependently. In vitro experiments indicated CGKYR increased IL-6 mRNA expression in human decidual stromal cells. CGKYR employs a multifaceted therapy for RPL complicated by insulin resistance, enhancing endometrial receptivity and stimulating HDSC proliferation by upregulating IL-6 mRNA expression in human decidual stromal cells.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.