ArticleAustralian veterinary journal2025
Cryptococcal meningitis due to Cryptococcus neoformans VNI in a koala (Phascolarctos cinereus) with progressive neurological disease.
Article in Australian veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cryptococcal meningitis due to Cryptococcus neoformans VNI in a koala (Phascolarctos cinereus) with progressive neurological disease.Australian veterinary journal · 2025Article
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7 authors.
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Abstract
Nearly all cases of cryptococcosis in koalas are caused by Cryptococcus gattii species complex. A rare case of meningitis due to Cryptococcus neoformans VNI/AFLP1 (abbreviated VNI) is described in a koala with nasal colonisation by both species complexes. An eight-year-old koala in a wildlife park presented for seizures and returned a positive latex cryptococcal antigen agglutination test. The koala was euthanased due to the severity of disease, and a post-mortem computed tomography study showed mild mucosal thickening of the right nasal turbinates. The necropsy also showed slightly turbid cisternal cerebrospinal fluid and meningeal opacity. Histology revealed severe granulomatous cryptococcal meningitis and paucireactive right cryptococcal rhinitis. Fungal cultures yielded heavy pure growths of C. neoformans from the brain and spinal cord, and comparable heavy growths of both C. neoformans and C. gattii from the nasal cavity. Cryptococcus species complexes were identified by mass spectrometry (MALDI-TOF) and multi-locus sequence typing (MLST). The C. neoformans isolates from the brain, spinal cord and nasal cavity were identical by MLST and classified as sequencing type (ST) 23 and molecular type (MT) VNI. The C. gattii isolates were classified as ST 51 and AFLP4/VGI (abbreviated VGI). This suggests that the meningitis developed as an extension of C. neoformans VNI from nasal cavity colonisation. This is the second documented case of central nervous system (CNS) cryptococcosis due to C. neoformans species complex in a koala and the first in Australia. Despite heavy nasal colonisation by C. gattii, only the C. neoformans isolate progressed to meningitis.
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