Trial reportThe American journal of psychiatry2025
Systemic Inflammation and Anhedonic Responses to an Inflammatory Challenge in Adults With Major Depressive Disorder: A Randomized Controlled Trial.
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in The American journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Anti-Inflammatory Treatment on Depressive Symptom Severity and Anhedonia in Depressed Individuals With Elevated Inflammation: Systematic Review and Meta-Analysis of Randomized Controlled Trials.The American journal of psychiatry · 2026Pooled it
- Obesity, low-grade inflammation, and inflammatory response to immune challenge modulate willingness to expend effort for reward.Brain, behavior, and immunity · 2026Trial
- Trial
- Higher Lipopolysaccharide Levels Are Linked to Less Anhedonia and Lower Severity of Major Depressive Disorder.Brain sciences · 2026Article
- Toward a Unified Neuroimmune Framework for Infection-Associated Psychiatric Disorders.Diseases (Basel, Switzerland) · 2026Review
- Neuroimmune Dysregulation and the Role of IL-10 in Depression: A Systematic Review.Brain sciences · 2026Review
- Inflammation, mental health, and alcohol behaviors: Testing links leveraging a familial community sample.Brain, behavior, & immunity - health · 2026Article
- Patient perspectives on the challenges, obstacles, and opportunities in discussing and managing anhedonia in major depressive disorder (MDD): a focus group study.Annals of general psychiatry · 2026Article
- Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis.medRxiv : the preprint server for health sciences · 2026Article
- The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review.Frontiers in pharmacology · 2026Review
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Inflammatory Cytokines as a Shared Pathophysiological Pathway in Depression and Chronic Insomnia: A Narrative Review of Mechanisms and Clinical Implications.Neuropsychiatric disease and treatment · 2026Review
- Sequential bilateral rTMS combined with fluoxetine for anhedonic depression in adolescents: clinical efficacy and peripheral inflammatory profiles.Frontiers in psychiatry · 2026Article
- Which aspects of anhedonia predict response to pharmacotherapy in major depressive disorder?Psychological medicine · 2025Article
- Recent Change in Anhedonia, Major Depression and Low-Grade Inflammation: Dangerous Liaisons? A Study Based on a Cohort Referred for Polysomnography.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Jonathan SavitzLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Leandra K Figueroa-HallLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
T Kent TeagueLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Hung-Wen YehLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Haixia ZhengLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Rayus KuplickiLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Kaiping BurrowsLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Nour El-SabbaghLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
MacGregor ThomasLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Isaac EwersLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Yoon-Hee ChaLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Salvador GuinjoanLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Sahib S KhalsaLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).ORCID 0000-0003-2124-8585
Martin P PaulusLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Michael R IrwinLaureate Institute for Brain Research, Tulsa, OK (Savitz, Figueroa-Hall, Zheng, Kuplicki, Burrows, El-Sabbagh, Ewers, Guinjoan, Khalsa, Paulus); Oxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK (Savitz, Guinjoan, Khalsa, Paulus); Department of Surgery (Teague, Guinjoan) and Department of Psychiatry (Guinjoan), University of Oklahoma School of Community Medicine, Tulsa, OK; Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK (Teague); Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO (Yeh); School of Medicine, University of Missouri-Kansas City, Kansas City, MO (Yeh); University of Oklahoma School of Medicine, Oklahoma City (Thomas); Department of Neurology, University of Minnesota School of Medicine, Minneapolis (Cha); Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles (Khalsa); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, and Department of Psychiatry and Biobehavioral Sciences at David Geffen School of Medicine, UCLA, Los Angeles (Irwin).
Funding
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Maëlle Camille Marie Gueguen · 2017 to 2026
$23.7MThe Impact of Maternal Adversity and Attachment Security on Infant Stress Reactivity: Prenatal Epigenetic PathwaysP20GM109097 · NIGMS · OSU CENTER FOR HEALTH SCIENCES · PI AMANDA S MORRIS · 2016 to 2026
$22.8MNeural response to inflammatory challenge in major depressive disorderR01MH123652 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI SAVITZ, JONATHAN · 2021 to 2025
$3.5MA neurocomputational assay of gastrointestinal interoception in anorexia nervosaR01MH127225 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB S., PAULUS, MARTIN P. · 2021 to 2025
$3.2MIn vivo inflammatory challenge to elucidate the role of the toll-like receptor 4 pathway in depressionR00MH126950 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Leandra Kali Figueroa-Hall · 2024 to 2026
$737kIn vivo inflammatory challenge to elucidate the role of the toll-like receptor 4 pathway in depressionK99MH126950 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI FIGUEROA-HALL, LEANDRA KALI · 2022 to 2023
$200kNIGMS NIH HHS P20 GM109097NIGMS NIH HHS P20 GM121312NIMH NIH HHS K99 MH126950NIMH NIH HHS L30 MH131119NIMH NIH HHS R00 MH126950NIMH NIH HHS R01 MH123652NIMH NIH HHS R01 MH127225
Abstract
objectiveThe authors sought to determine whether an inflammatory challenge with lipopolysaccharide (LPS) differentially impacts symptoms of anhedonia in participants with major depressive disorder with high (≥3 mg/L) and low (≤1.5 mg/L) serum C-reactive protein (CRP) concentrations.
methodsSixty-eight participants with major depressive disorder were randomly assigned, in a 1:1 ratio, to receive LPS (0.8 ng/kg body weight) or placebo (saline) in a parallel-group double-blind design. Participants were stratified according to baseline CRP concentrations, yielding four groups: high-CRP LPS (N=13), low-CRP LPS (N=19), high-CRP placebo (N=13), and low-CRP placebo (N=19). Blood was sampled at baseline, at 1, 1.5, 3.5, 6, and 24 hours, and 1 week after LPS or saline administration, with concurrent assessment of psychological outcomes. The primary outcome measure was the Snaith-Hamilton Pleasure Scale (SHAPS), and the primary contrast of interest was the change between baseline and 1.5 hours (peak of the inflammatory response) in the high-CRP versus low-CRP groups receiving LPS. Secondary outcomes included the Montgomery-Åsberg Depression Rating Scale (MADRS) and serum levels of three cytokines: interleukin-6 (IL-6), IL-10, and tumor necrosis factor (TNF). Data were analyzed with linear mixed models.
resultsSignificantly greater increases in self-reported anhedonia (on the SHAPS) and IL-6 levels were observed between baseline and 1.5 hours in the high-CRP versus low-CRP LPS groups. There were no significant differences for TNF and IL-10. The MADRS was not administered at 1.5 hours; secondary analyses showed a significant group-by-condition-by-time interaction driven by a greater decrease in MADRS scores between baseline and 24 hours in the high-CRP group.
conclusionsDepressed individuals with systemic inflammation appeared to be biologically primed to respond more strongly to inflammatory stimuli, and psychologically, this sensitization impacted the symptom of anhedonia, the primary outcome.
Indexed as
AnhedoniaC-Reactive ProteinInflammationLipopolysaccharidesMajor Depressive DisorderAdultDouble-Blind MethodFemaleHumansInterleukin-6MaleMiddle AgedTumor Necrosis Factor-alphaC-Reactive ProteinInterleukin-6LipopolysaccharidesTumor Necrosis Factor-alphaDepressive DisordersInflammationMajor Depressive Disorder
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.