Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report.

Sphoorthi Anup Belludi, Sharaz Shaik, Neha Pradhan, Sreeparvathy Rema

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Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Sphoorthi Anup BelludiDepartment of Periodontics, K.L.E Society's Institute of Dental Sciences, Bengaluru, Karnataka, India.ORCID https://orcid.org/0000-0003-1148-7873

Sharaz ShaikLincoln University PhD Program, Lenora Institute of Dental Science, Rajahmundry, Andhra Pradesh, India.

Neha PradhanDepartment of Periodontics, K.L.E Society's Institute of Dental Sciences, Bengaluru, Karnataka, India.

Sreeparvathy RemaDepartment of Periodontics, K.L.E Society's Institute of Dental Sciences, Bengaluru, Karnataka, India.

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6 · The paper itself

Abstract

In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, and obturation. Later, we reflected a full-thickness mucoperiosteal flap and thoroughly debrided the granulation tissue. We filled the defect with a gel containing PBMSCs and PRFM, prepared from the patient's peripheral blood, and sutured the flap. After nine months, we noticed significant osseous fill and 5 mm of gain in the clinical attachment level. The outcomes of the case show the periodontal regenerative potential of the novel combination.

Indexed as

Endo-periodontal lesionPeripheral blood stem cellsPlatelet-rich fibrinRegenerative endodontics

Identifiers

PMID40265038

DOI10.34172/japid.025.3502

PMCPMC12010481

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