A case of acute macular neuroretinopathy in a pediatric patient with optic neuritis.

Ami Nakagawa, Sujin Hoshi, Tetsuro Oshika

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Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Ami NakagawaDepartment of Ophthalmology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki, Japan.

Sujin HoshiDepartment of Ophthalmology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki, Japan.

Tetsuro OshikaDepartment of Ophthalmology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Acute macular neuroretinopathy (AMN) is a retinal disorder caused by ischemia in the deep capillary plexus. There have been several reports of AMN associated with optic neuritis in adults. We report a case of AMN associated with optic neuritis in a pediatric patient. Case report: A 14-year-old boy presented with ocular pain upon eye movement and decreased vision with disc edema in the right eye, leading to a diagnosis of optic neuritis. After initiating steroid pulse therapy, his visual acuity improved promptly. Optical coherence tomography revealed a hyperreflective area in the outer retina on the nasal side of the macula, and fundus examination showed a reddish-brown, wedge-shaped lesion, confirming the diagnosis of AMN. The case was ultimately diagnosed as myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease. Post-treatment, visual acuity improved; however, a paracentral scotoma attributed to AMN remained. Discussion and conclusion: The pathogenesis of AMN in cases of optic neuritis may involve mechanical arterial occlusion due to optic disc swelling. Regardless of age, careful fundus examination is necessary during the clinical course of optic neuritis, and MOG-immunoglobulin G testing can be considered for patients showing optic neuritis with AMN.

Indexed as

Acute macular neuroretinopathyMyelin oligodendrocyte glycoprotein antibody-associated diseaseOptical coherence tomographyOptic neuritisPediatric patient

Identifiers

PMID40265085

DOI10.1016/j.ajoc.2025.102332

PMCPMC12013104

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