Evidence mapPaperPMID 40265372Full record

ReviewEuropean burn journal2025

Metabolic and Hormonal Changes in Pediatric Burn Patients: Mechanisms, Evidence, and Care Strategies.

Gloria Pelizzo, Valeria Calcaterra, Michela Marinaro, Paola Baldassarre, Carlotta Paola Maria Canonica, Gianvincenzo Zuccotti

Abstract readReview
In one paragraph

Review in European burn journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gloria PelizzoDepartment of Biomedical and Clinical Science, University of Milan, 20157 Milan, Italy.
Valeria CalcaterraPediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2137-5974
Michela MarinaroPediatric Surgery Department, Buzzi Children's Hospital, 20154 Milan, Italy.
Paola BaldassarrePediatric Department, Buzzi Children's Hospital, 20154 Milan, Italy.
Carlotta Paola Maria CanonicaPediatric Surgery Department, Buzzi Children's Hospital, 20154 Milan, Italy.ORCID 0009-0003-9119-3492
Gianvincenzo ZuccottiDepartment of Biomedical and Clinical Science, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2795-9874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBurn injuries constitute a significant global health challenge, especially in pediatric populations, where they are a leading cause of morbidity and mortality. Pediatric burns require particular attention due to their unique pathophysiology, long-term consequences on growth and development, and psychological impacts.

methodsWe propose a comprehensive review of recent advancements in understanding the key aspects of hormonal and metabolic changes in burned children, aiming to guide therapeutic interventions, improve outcomes, and reduce the global burden of these injuries.

resultsEffective management of the physiological stress response in pediatric burn patients necessitates a multidisciplinary approach integrating medical, nutritional, and rehabilitative strategies. Timely nutritional support and individualized plans preserve muscle mass, promote wound healing, and reduce complications and organ dysfunction risk. Advances in pharmacological interventions, such as beta-blockers, anabolic agents, and hormonal treatment, offer promising pathways to improve recovery and mitigate long-term complications. Early mobilization and physiotherapy are essential for preventing complications of prolonged immobility, including muscle wasting, joint contractures, and functional decline; their effectiveness is closely tied to advancements in minimally invasive procedures, regenerative medicine, and reconstructive techniques, particularly for pediatric patients.

conclusionsWhile current strategies have significantly improved survival and outcomes for pediatric burn patients, ongoing research is critical to refine these new care strategies.

Indexed as

burnscare strategieschildrenhormonal changesmetabolic changespediatricspediatric surgerypharmacological interventions

Identifiers

PMID40265372
PMCPMC12015776

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.