Evidence map›Paper›PMID 40266361›Full record

ArticleMolecular biology reports2025

Upregulation of antioxidant genes in antimony-resistant Leishmania tropica clinical isolates.

Maryam Ahmadpour, Hakimeh Torkian Valashani, Saied Reza Naddaf, Mehdi Mohebali, Homa Hajjaran, Behnaz Ghazineghad, Romana Khosravi, Parisa Mousavi, Elham Kazemirad

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Maryam AhmadpourDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran.
Hakimeh Torkian ValashaniDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran.
Saied Reza NaddafDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran.
Mehdi MohebaliDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Homa HajjaranDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Behnaz GhazineghadDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran.
Romana KhosraviDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Parisa MousaviSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Elham KazemiradDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran. ekazemirad@yahoo.com.

Funding

Pasteur Institute of Iran, Iran, Islamic Republic Of 482
6 · The paper itself

Abstract

backgroundIncreasing resistance to antimonial drugs has become a significant challenge in effective treatment in endemic regions of leishmaniasis. Antioxidant defense plays a crucial role in antimony resistance by combating antimonial-induced oxidative stress. Accordingly, we investigated the transcript levels of some antioxidant genes in antimony-sensitive and resistant clinical Leishmania tropica isolates.

methodsIn the current study, 22 Leishmania tropica isolates from ACL patients who presented responsive or unresponsive to antimony were examined. The susceptibility of parasites against SbV and hydrogen peroxide (H

resultsThe in-vitro susceptibility to SbV in intracellular amastigotes revealed 3.82 times higher IC

conclusionsThe data presented here revealed a phenotypic heterogeneity in antioxidant gene expression among L. tropica clinical isolates. Overall, the upregulation of genes involved in antioxidant defense could probably contribute to natural antimony resistance in L. tropica clinical isolates.

Indexed as

AntimonyAntioxidantsDrug ResistanceLeishmania tropicaAntiprotozoal AgentsAscorbate PeroxidasesHumansHydrogen PeroxideLeishmaniasis, CutaneousOxidative StressPeroxidasesProtozoan ProteinsThioredoxinsUp-RegulationAntimonyAntioxidantsAntiprotozoal AgentsAscorbate PeroxidasesHydrogen PeroxidePeroxidasesProtozoan ProteinsThioredoxinstryparedoxin peroxidaseAntioxidant genesLeishmania tropicaNatural antimony resistanceReal-time RT-PCR

Identifiers

PMID40266361

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.