ArticleMolecular biology of the cell2025
M phase-specific generation of supernumerary centrioles in cancer cells.
Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Many cancer cells maintain supernumerary centrioles, despite the potential risks associated with catastrophic outcomes during mitosis. In this study, we searched for cancer cell lines in which supernumerary centrioles are generated during the M phase and identified a few cell lines among the dozen examined. PLK4 activity is also required for M phase-specific generation of supernumerary centrioles. We observed that mitotic centrioles prematurely separate in many cancer cells when levels of pericentriolar material (PCM) proteins, such as PCNT and CEP215, are low. Furthermore, the presence of supernumerary centrioles was correlated with reduced mitotic PCM levels. Notably, overexpression of PCNT led to a reduction in supernumerary centrioles in MDA-MB-157 cells. These findings suggest that diminution of mitotic PCM may be a cause of M phase-specific generation of supernumerary centrioles in selected cancer cells.
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