Evidence map›Paper›PMID 40266815›Full record

ArticleMolecular biology of the cell2025

Isoform-specific phosphorylation of axonemal dynein heavy chains.

Miho Sakato-Antoku, Ramila S Patel-King, Kazuo Inaba, Jeremy L Balsbaugh, Stephen M King

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miho Sakato-AntokuDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.
Ramila S Patel-KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.
Kazuo InabaShimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Jeremy L BalsbaughProteomics and Metabolomics Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, CT 06269.
Stephen M KingDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030-3305.ORCID 0000-0002-5484-5530

Funding

The Biology of Motile CiliaR35GM140631 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Stephen M King · 2021 to 2026
$4.2M
Thermo Scientific Orbitrap Eclipse Tribrid ETD Mass Spectrometer for UConn ProteomicsS10OD028445 · OD · UNIVERSITY OF CONNECTICUT STORRS · PI BALSBAUGH, JEREMY · 2021 to 2021
$994k
NIGMS NIH HHS R35 GM140631NIH HHS S10 OD028445
6 · The paper itself

Abstract

Axonemal dyneins power ciliary motility and phosphorylation of key intermediate and light chain components affects the regulation and properties of these motors in very distantly related organisms. It is also known that many axonemal dynein heavy chains are subject to this posttranslational modification although this has been little studied. Here we examine axonemal dynein heavy chains from a broad range of ciliated eukaryotes and identify phosphorylated sites embedded within various kinase recognition motifs such as those for protein kinase A, protein kinase C, and casein kinase II. Mapping these sites onto discrete heavy chain types reveals class-specific locations apparently mediated by different kinases. For example, we find that all

Indexed as

Axonemal DyneinsDyneinsAmino Acid SequenceAnimalsAxonemeChlamydomonasChlamydomonas reinhardtiiCiliaPhosphorylationProtein IsoformsAxonemal DyneinsDyneinsProtein Isoforms

Identifiers

PMID40266815
PMCPMC12206504

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.