Evidence map›Paper›PMID 40267129›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A selfish supergene causes meiotic drive through both sexes in

Graeme L Keais, Chadi M Saad-Roy, Emmanuel Gonzalez-Sqalli, Candice N Powell, Loren H Rieseberg, Ryan M R Gawryluk, P van den Driessche, Kevin H-C Wei, Benjamin Loppin, Steve J Perlman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026
    Article
  6. A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Graeme L KeaisDepartment of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada.ORCID 0000-0002-5567-7946
Chadi M Saad-RoyMiller Institute for Basic Research in Science, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0002-2217-3071
Emmanuel Gonzalez-SqalliLaboratoire de Biologie et Modélisation de la Cellule, École Normale Supérieure de Lyon, CNRS UMR5239, Université Claude Bernard Lyon 1, Lyon, France 69364.ORCID 0009-0004-3589-5876
Candice N PowellDepartment of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada.
Loren H RiesebergDepartment of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-2712-2417
Ryan M R GawrylukDepartment of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada.ORCID 0000-0003-1251-882X
P van den DriesscheDepartment of Mathematics and Statistics, University of Victoria, Victoria, BC V8W 2Y2, Canada.ORCID 0000-0003-1485-8326
Kevin H-C WeiDepartment of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-1694-9582
Benjamin LoppinLaboratoire de Biologie et Modélisation de la Cellule, École Normale Supérieure de Lyon, CNRS UMR5239, Université Claude Bernard Lyon 1, Lyon, France 69364.ORCID 0000-0002-7166-9233
Steve J PerlmanDepartment of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada.ORCID 0000-0002-9020-5506

Funding

Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley (MIBRS) N/ACanadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) N/AFrench National Research Agency ANR-21-CE13-0037
6 · The paper itself

Abstract

Meiotic drivers are selfish genetic elements that bias their own transmission during meiosis or gamete formation. Due to the fundamental differences between male and female meiosis in animals and plants, meiotic drivers operate through distinct mechanisms in the two sexes: In females, they exploit the asymmetry of meiosis to ensure their inclusion in the egg, whereas in males, they eliminate competing gametes after symmetric meiosis. Meiotic drive is commonly reported in males, where it strongly influences the evolution of spermatogenesis, while the few known cases in females have highlighted its crucial role in centromere evolution. Despite a growing number of examples in a wide range of organisms, meiotic drive has so far only been observed in one sex or the other since its discovery nearly 100 y ago. Here, we show that a selfish X chromosome known to cause meiotic drive in male

Indexed as

DrosophilaMeiosisX ChromosomeAnimalsDrosophila melanogasterEvolution, MolecularFemaleMaleRecombination, Geneticmeiotic driveselfish genetic elementssex chromosomesupergenes

Identifiers

PMID40267129
PMCPMC12054836

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.